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Lindoldhamine can activate the human ASIC3 channel
Researchers from the Laboratory of Neuroreceptors and Neuroregulators (group leader - Sergei Kozlov) found alkaloid lindoldhamine in the leaves of the noble laurel, which can activate the human ASIC3 channel at physiological pH.
Acid-sensitive ion channels (ASICs) - neuronal receptors, that are involved in key processes of the nervous system such as synaptic plasticity, learning, pain sensitivity and a number of other functions. ASICs make the significant contribution to the development of neurological and psychiatric diseases, but the lack of efficient and selective activators and inhibitors of these channels devaluate them as pharmacological targets.
Researchers from the Laboratory of Neuroreceptors and Neuroregulators (group leader - Sergei Kozlov) found alkaloid lindoldhamine in the leaves of the noble laurel, which can activate the human ASIC3 channel at physiological pH. They reported that acidification of the extracellular medium is not essential for the opening of this channel. The article is published in the British Journal of Pharmacology. Molecules, closely related to the structure of lindolhamine, are produced in the human body during the inflammation and can also activate and alter the functioning of acid-sensitive channels. Regulation of the intracellular synthesis pathways of these endogenous molecules can be a new therapeutic strategy for a novel therapeutic strategy for treatment of pain and inflammation, the researchers wrote in a second article published in the Frontiers in Molecular Neuroscience journal.
march 23, 2018