Video from the 42th Seminar of the Young scientists counsil
Calcineurin inhibitors such as cyclosporine and tacrolimus are the key elements in immunosuppressive therapy of patients underwent organ transplantation. Despite high effectiveness of such treatment significant renal and neurological adverse effects are limiting its use.
Kerim in his work studies physiological role of calcineurine in cathion-chloride transporters regulation through dephosphorilation. He shows that calcineurine inhibitors-associated side-effects are caused by high phosphorilation level of these transporters in kidneys, and it seems that neurons are affected by same mechanism.
Presented results open new perspectives in prevention and diminishing immunosuppresive therapy adverse effects and quality of life improvement in patients with transplanted organs.