Russ. J. Bioorganic Chem., 2004, 30(6):553-560

Ribavirin: Biotechnological synthesis and effect on the reproduction of Vaccinia virus

The biotechnological method of synthesis of ribavirin, vidarabin, and 6-azauridine by the use of immobilized recombinant enzymatic preparations of nucleoside phosphorylase was improved. The effect of ribavirin and its combinations with the other synthesized nucleosides on the reproduction of Vaccinia virus was studied on the culture of Vero cells. The combination of ribavirin and vidarabin was shown to provide the antiviral effect at lesser concentrations than with these compounds taken separately.

Konstantinova ID, Leonteva NA, Galegov GA, Ryzhova OI, Chuvikovskii DV, Antonov KV, Esipov RS, Taran SA, Verevkina KN, Feofanov SA, Miroshnikov AI

IBCH: 1334
Ссылка на статью в журнале: http://link.springer.com/10.1023/B:RUBI.0000049772.18675.34
Кол-во цитирований на 01.2024: 13
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