Tetrahedron, 2018, 74(52):7442-7449
Astolides A and B, antifungal and cytotoxic naphthoquinone-derived polyol macrolactones from Streptomyces hygroscopicus
The structures were elucidated by interpretation of UV spectroscopic, MS, 1D and 2D NMR data. The relative configurations were determined by analysis of NOESY/ROESY spectra and coupling constants. The isolated compounds were evaluated for their inhibitory activity against bacteria, fungi and yeasts and showed pronounced antifungal activity. Both compounds are noticeably cytotoxic, being active against doxorubicin-resistant human leukemia cell line.
Scopus: 2-s2.0-85056644734
IBCH: 7417
Ссылка на статью в журнале: https://linkinghub.elsevier.com/retrieve/pii/S0040402018313553
Кол-во цитирований на 02.2024: 15
Данные статьи проверены модераторами 2018-11-13