- science news Toxin from black mamba venom inhibits growth of glioma cells selectively expressing ASIC1a channels
Gliomas are fast growing and highly invasive brain tumors, characterized by tumor microenvironment acidification that drives glioma cell growth and migration. Channels containing Acid-sensing Ion Channel 1a subunit (ASIC1a) mediate amiloride-sensitive cation influx in late stage glioma cells, but not in normal astrocytes. Thus, selective targeting of ASIC1a can be a perspective strategy for glioma treatment.
- science news Start codon context and occurrence of AUG codons in the beginning of protein coding open reading frames co-evolve
Researchers from IBCh RAS together with their international collаborators discovered an evolutionary link between efficiency of start codons and the probability of AUG codon occurrence in the 5'-end parts of protein-coding sequences. When start codons are inefficient the next AUG codon is more likely to be found in the same reading frame. At the same time in case of highly efficient start codons, the next AUG codon is more likely to be found in alternative frames. They also have shown that weak initiation at the first starts is associated with the synthesis of shortened proteoforms as a result of initiation at the second starts.
- science news New technology promises to revolutionize nanomedicine
A collaboration of scientists from the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, the Moscow Institute of Physics and Technology and Prokhorov General Physics Institute of the Russian Academy of Sciences have developed a breakthrough technology to resolve a key problem that has prevented the introduction of novel drugs into clinical practice for decades. The study was published in Nature Biomedical Engineering and featured in the journal’s News & Views section.
- science news A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding
Kinase-mediated phosphorylation represents one of the general strategies for the emergence of antibiotic resistance. A new subfamily of AmiN-like kinases, isolated from the Siberian bear microbiome, inactivates antibiotic amicoumacin by phosphorylation. The nanomolar substrate affinity defines AmiN as a phosphotransferase with a unique catalytic efficiency proximal to the diffusion limit. Crystallographic analysis and multiscale simulations revealed a catalytically perfect mechanism providing phosphorylation exclusively in the case of a closed active site that counteracts substrate promiscuity. AmiN kinase is a member of the previously unknown subfamily representing the first evidence of a specialized phosphotransferase bioscavenger.
- science news Transgenic aspen plants (Populus tremula) with the expression of recombinant xyloglucanase sp-Xeg show an increased growth rate, altered composition and properties of wood, and the phenotype of the plant as a whole
Scientists from the Group of Forest Biotechnology IBCh RAS obtained the transgenic aspen with acceletated growth, a modified carbohydrate composition and a slower rate of decomposition of wood.
- science news Structure of Supramers Formed by the Amphiphile Biotin‐CMG‐DOPE
Scientists from the Department of Chemical Biology of Glycans and Lipids, the Department of structural biology and the Department of Biomaterials and Bionanotechnology IBCh RAS in collaboration with Russian and foreign colleges published a paper in ChemistryOpen on the study of conjugate of a biotin with DOPE (dioleoylphosphatidyl ethanolamine) and on its interaction with streptavidin.
- science news Soluble Variant of Human Lynx1 Positively Modulates Synaptic Plasticity and Ameliorates Cognitive Impairment Associated with α7-nAChR Dysfunction
Scientists from the Laboratory of bioengineering of neuromodulators and neuroreceptors, the Laboratory of structural biology of ion channels and the Laboratory of neuroreceptors and neuroregulators Shemyakin-Ovchnnikov Institute together with colleagues from the Faculty of biology of Moscow State University and other russian scientific institutes, found that the intranasal administration of the water-soluble analogue of the human neuromodulator Lynx1 can prevent cognitive impairment associated with dysfunction of the α7 type nicotinic acetylcholine receptor.
- science news Pyrophosphate pharmacophore model: How nisin captures lipid II
Researchers from the Group of in silico analysis of membrane proteins structure and the Laboratory of biomolecular modeling of IBCh RAS have predicted the structure of the complex between lantibiotic nisin with the bacterial cell wall precursor — lipid II — on the membrane surface.
- science news How the fluorescent nanoclusters look like
Our new article “Albumin-stabilized fluorescent metal nanoclusters: fabrication, physico-chemical properties and cytotoxicity” was recently published in Materials and Design journal. The work was performed by a team of authors from the Scientific Clinical Center for Physico-Chemical Medicine, Moscow Institute of Physics and Technology and IBCh RAS. The researchers of the Electron microscopy group of our institute carried out an important part of the work on direct visualization of the obtained structures, as well as on the measurement of energy dispersive X-ray spectra.
- science news The role of chloroplast protein remodeling in stress responses and shaping of the plant peptidome
Researchers of the Laboratory of plant functional genomics and proteomics, IBCh RAS, in collaboration with Laboratory of molecular basis of plant stress resistance, IBCh RAS, and James Hutton Institute (United Kingdom) published a review article in the international peer-reviewed scientific journal New Phytologist (IF = 7.29). This review “The role of chloroplast protein remodeling in stress responses and shaping of the plant peptidome” is focused on processes of reorganization of the chloroplast proteome under stress conditions and on the roles of bioactive peptides generated from chloroplast proteins.
- conferences Lipids 2021 Conference
October 19–21, 2021
Lipids 2021 Conference, October 19-21, 2021, IBCH RAS, Moscow
- science news Lecture by Director-General of the ICGEB Lawrence Banks «Human Papillomaviruses: From Infectious Entry to Malignancy»
January 27 (This event is over)
ICGEB Director-General Group Leader Lawrence Banks will deliver a lecture entitled «Human Papillomaviruses: From Infectious Entry to Malignancy». Date and time: Mon 27 January 2020 14:00. Location: Small conference hall at 3rd floor BON IBCh.
- science news LIGHTS ON: Molecular Imaging of disease dynamics in vivo
September 27 October 11, 2019 (This event is over)
Abhijit De PhD Scientific Officer ‘F’ and Principal Investigator Head, Molecular Functional Imaging Lab Advanced Centre of Training Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India.
- science news Seminar "Molecular Brain": Anton Maximov
October 8, 2019 (This event is over)
The seminar will be held on the 8th of October at 3 pm in the Small lecture hall (3rd floor, BON, IBCh). Everyone is welcome!
- conferences II Joint Life Sciences Forum: VI Russian Congress on Biochemistry and IX Russian Symposium «Proteins and Peptides»
October 1–6, 2019 (This event is over)
Dear Colleagues! We are pleasure to invite you to participate the VI Russian Congress on Biochemistry, which will be held in Sochi, Russia (Dagomys Hotel) on October 1-6, 2019.
- science news Lecture by Prof. Yibo Wang «Drug Discovery Targeting Transmembrane Protein-Protein Interactions»
August 26, 2019 (This event is over)
Prof. Yibo Wang from the Changchun Institute of Applied Chemistry will deliver a lecture entitled «Drug Discovery Targeting Transmembrane Protein-Protein Interactions». Date and time: Mon 26 August 2019 11:30. Location: Conference hall at 5th floor BON IBCh.
- conferences 12th INTERNATIONAL CONFERENCE “BIOCATALYSIS.FUNDAMENTALS & APPLICATIONS” “BIOCATALYSIS-2019”
June 24–28, 2019 (This event is over)
Dear colleagues, The Lomonosov Moscow State University and RAS institutes, including IBCH RAS, is planning to convene a traditional biannual 12 th International Conference "BIOCATALYSIS-2019" in June, 24–28, 2019. Conference will be convened on board a ship cruising via the route St. Petersburg – Valaam – Kizhi – St. Petersburg. More info is available at http://bc2019.org/.
- science news Scientific School for young scientists «Structural biology: main problems and approaches to their solution»
June 6, 2019 (This event is over)
Dear colleagues! The Scientific School is devoted to the latest achievements and methods in the field of structural research will be held at the IBCh RAS on Thursday, 6 June 2019. The scientific program of the School includes lectures by leading scientists working in various fields of molecular biology and representing the basic structural methods, namely, X-ray Crystallography, Cryo-Electron Microscopy, NMR-spectroscopy and computer modeling.
- science news "Molecular Brain" seminar
April 16, 2019 (This event is over)
The seminar is timed to the birthday of academician Eugene Grishin and will take place on April 16 at 14:00 in the Hall of Academic Council. Members of the Department of Molecular Neurobiology created by Eugene, will give talks on their present work. Everyone is cordially invited.
- science news Microscopic Imaging of Epigenetic Landscape - A Universal Platform to Study Epigenetic Changes at Single Cell Level
February 15, 2019 (This event is over)