- science news PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia
Protein arginine methyltransferase 5 (PRMT5) belongs to the class II arginine methyltransferases and catalyzes monomethylation and symmetrical dimethylation of arginines on proteins. It has recently emerged as a promising cancer drug target, and two PRMT5 inhibitors are currently in clinical trials for a range malignancies. Despite the recognized therapeutic potential, it is unclear which PRMT5 functions underlie its oncogenic activity.
- science news A previously unknown modulator of purinergic and FGF-signalization, c-Answer, that stimulates regeneration in cold-blooded animals was lost by poorly regenerating warm-blooded animals, including humans
A group of scientists from the Laboratory of Molecular Bases of Embryogenesis, IBCh RAS, together with colleagues from the Laboratory of Mathematical Methods and Models in Bioinformatics, IPPI RAS developed a bioinformatics method that allows one to reveal genes that appear or disappear at a certain stage of evolution. Using this method, a number of genes were found that disappeared in warm-blooded animals, including humans.
- science news Peptides encoded by short open reading frames regulate plant growth and development
All genomes contain millions of short open reading frames (<100 codons) that are discarded during genome annotation. Recently, it has been shown that peptides encoded by short open reading frames can perform many important functions in animal cells.
- science news The secret of fireworm is out: molecular basis of Odontosyllis bioluminescence
Researchers discovered the biomolecular mechanism of fireworm glow.
- science news Seminar by Prof. Ilya Vinnikov «The top-down strategy in deciphering the roles of microRNAs in the metabolic and neurodegenerative models»
Prof. Ilya Vinnikov from the Shanghai Jiao Tong University will deliver a lecture entitled «The top-down strategy in deciphering the roles of microRNAs in the metabolic and neurodegenerative models». Date and time: Tue 20 August 2019 14:00. Location: Conference hall at 5th floor BON IBCh.
- science news Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T cell
Efficient and specific removal of malignant cells is the ultimate goal of cancer therapy. The current rapid development of chimeric antigen receptor T cell (CAR-T cell or CART) therapy potentially provides high efficiency and allows long-term surveillance, which have greatly extended the frontier of leukemia treatment.
- science news Nobel Prize winner, Arieh Warshel took part in the meeting of the IBCh RAS scientific council and joined the international advisory Board of the Institute
April 3rd 2019, a regular meeting of the IBCh RAS Scientific Council took place, featuring the 2013 Chemistry Nobel Prize awardee, Arieh Warshel. The scientist delivered a short talk, regarding the prospects of contemporary science and possibilities of using the quantum mechanics calculations to predict the behavior of complex systems, up to the organs and organisms. Director of our Institute, Alexander Gabibov, announced that professor Warshel had joined the International Advisory Board of the Institute, along with several other distinguished scientists, and presented him a symbolical gift.
- science news Scientists present a fully genetically encodable bioluminescent system
November 26, 2018
Scientists from Russia, UK, Spain, Brazil, Japan, and Austria discovered the essential set of enzymes that allows glowing fungi to emit light. The bioluminescent system includes a brand- new luciferase and three enzymes that enable biosynthesis of fungal luciferin from a widespread metabolite – caffeic acid – as well as its recycling. The genes encoding this “caffeic acid cycle” make up a unique molecular toolkit that allows to turn any higher organism into a glowing one. The work was published in Proceedings of the National Academy of Sciences of the United States of America.
- science news Kurt Wüthrich took part in the workshop of the Structural biology department
October 10, 2018
Professor Kurt Wüthrich, Nobel Laureate in Chemistry, 2002, visited Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS and took part in the workshop of the Structural biology department of the Institute (headed by Prof. Alexander Arseniev).
- science news Ras-dva: make regeneration great again
September 17, 2018
The researchers from Laboratory of molecular bases of embryogenesis recently hypothesised that the decrease of limb regeneration capacity in amniotes (reptiles, birds and mammals) could be caused by elimination in evolution of genes, encoding for important regulators of specific wound epithelium and blastema organization, which are used by excellent regenerating anamniotes (fish and amphibia). Using two anamniotic model organisms Danio rerio adult fishes and Xenopus laevis tadpoles the authors have shown the essential role of Ras-dva small GTPases in regulation of these processes, meanwhile their genes are eliminated in a stepwise manner during evolution till total absence in placental mammals. The obtained results support the hypothesis. The investigation is published in Scientific reports.
- science news LIGHTS ON: Molecular Imaging of disease dynamics in vivo
September 27 October 11 (This event is over)
Abhijit De PhD Scientific Officer ‘F’ and Principal Investigator Head, Molecular Functional Imaging Lab Advanced Centre of Training Research and Education in Cancer, Tata Memorial Centre, Kharghar, Navi Mumbai, India.
- science news Seminar "Molecular Brain": Anton Maximov
October 8 (This event is over)
The seminar will be held on the 8th of October at 3 pm in the Small lecture hall (3rd floor, BON, IBCh). Everyone is welcome!
- conferences II Joint Life Sciences Forum: VI Russian Congress on Biochemistry and IX Russian Symposium «Proteins and Peptides»
October 1–6 (This event is over)
Dear Colleagues! We are pleasure to invite you to participate the VI Russian Congress on Biochemistry, which will be held in Sochi, Russia (Dagomys Hotel) on October 1-6, 2019.
- science news Lecture by Prof. Yibo Wang «Drug Discovery Targeting Transmembrane Protein-Protein Interactions»
August 26 (This event is over)
Prof. Yibo Wang from the Changchun Institute of Applied Chemistry will deliver a lecture entitled «Drug Discovery Targeting Transmembrane Protein-Protein Interactions». Date and time: Mon 26 August 2019 11:30. Location: Conference hall at 5th floor BON IBCh.
- conferences 12th INTERNATIONAL CONFERENCE “BIOCATALYSIS.FUNDAMENTALS & APPLICATIONS” “BIOCATALYSIS-2019”
June 24–28 (This event is over)
Dear colleagues, The Lomonosov Moscow State University and RAS institutes, including IBCH RAS, is planning to convene a traditional biannual 12 th International Conference "BIOCATALYSIS-2019" in June, 24–28, 2019. Conference will be convened on board a ship cruising via the route St. Petersburg – Valaam – Kizhi – St. Petersburg. More info is available at http://bc2019.org/.
- science news Scientific School for young scientists «Structural biology: main problems and approaches to their solution»
June 6 (This event is over)
Dear colleagues! The Scientific School is devoted to the latest achievements and methods in the field of structural research will be held at the IBCh RAS on Thursday, 6 June 2019. The scientific program of the School includes lectures by leading scientists working in various fields of molecular biology and representing the basic structural methods, namely, X-ray Crystallography, Cryo-Electron Microscopy, NMR-spectroscopy and computer modeling.
- science news "Molecular Brain" seminar
April 16 (This event is over)
The seminar is timed to the birthday of academician Eugene Grishin and will take place on April 16 at 14:00 in the Hall of Academic Council. Members of the Department of Molecular Neurobiology created by Eugene, will give talks on their present work. Everyone is cordially invited.
- science news Microscopic Imaging of Epigenetic Landscape - A Universal Platform to Study Epigenetic Changes at Single Cell Level
February 15 (This event is over)
- science news "Molecular Brain" seminar
January 22 (This event is over)
The seminar will take place on January 22 at 16:00 in the Minor hall. Professor Leonard Khiroug from the University of Helsinki (Finland) will talk about the "awake microscopy" methodology utilized for high-resolution brain imaging. Everyone is cordially invited.
- science news Lecture by Prof. Zhang Shuguang «The QTY Code: A tool for designing detergent-free membrane proteins»
December 24, 2018 (This event is over)
Prof. Zhang Shuguang from MIT will deliver a lecture entitled «The QTY Code: A tool for designing detergent-free membrane proteins». Date and time: Mon 24 December 2018 15:00. Location: Conference hall at 3rd floor BON IBCh.