- science news Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T cell
Efficient and specific removal of malignant cells is the ultimate goal of cancer therapy. The current rapid development of chimeric antigen receptor T cell (CAR-T cell or CART) therapy potentially provides high efficiency and allows long-term surveillance, which have greatly extended the frontier of leukemia treatment.
- science news Nobel Prize winner, Arieh Warshel took part in the meeting of the IBCh RAS scientific council and joined the international advisory Board of the Institute
April 3rd 2019, a regular meeting of the IBCh RAS Scientific Council took place, featuring the 2013 Chemistry Nobel Prize awardee, Arieh Warshel. The scientist delivered a short talk, regarding the prospects of contemporary science and possibilities of using the quantum mechanics calculations to predict the behavior of complex systems, up to the organs and organisms. Director of our Institute, Alexander Gabibov, announced that professor Warshel had joined the International Advisory Board of the Institute, along with several other distinguished scientists, and presented him a symbolical gift.
- science news Scientists present a fully genetically encodable bioluminescent system
November 26, 2018
Scientists from Russia, UK, Spain, Brazil, Japan, and Austria discovered the essential set of enzymes that allows glowing fungi to emit light. The bioluminescent system includes a brand- new luciferase and three enzymes that enable biosynthesis of fungal luciferin from a widespread metabolite – caffeic acid – as well as its recycling. The genes encoding this “caffeic acid cycle” make up a unique molecular toolkit that allows to turn any higher organism into a glowing one. The work was published in Proceedings of the National Academy of Sciences of the United States of America.
- science news Kurt Wüthrich took part in the workshop of the Structural biology department
October 10, 2018
Professor Kurt Wüthrich, Nobel Laureate in Chemistry, 2002, visited Shemyakin–Ovchinnikov Institute of bioorganic chemistry RAS and took part in the workshop of the Structural biology department of the Institute (headed by Prof. Alexander Arseniev).
- science news Ras-dva: make regeneration great again
September 17, 2018
The researchers from Laboratory of molecular bases of embryogenesis recently hypothesised that the decrease of limb regeneration capacity in amniotes (reptiles, birds and mammals) could be caused by elimination in evolution of genes, encoding for important regulators of specific wound epithelium and blastema organization, which are used by excellent regenerating anamniotes (fish and amphibia). Using two anamniotic model organisms Danio rerio adult fishes and Xenopus laevis tadpoles the authors have shown the essential role of Ras-dva small GTPases in regulation of these processes, meanwhile their genes are eliminated in a stepwise manner during evolution till total absence in placental mammals. The obtained results support the hypothesis. The investigation is published in Scientific reports.
- science news A bright bantam: BrUSLEE – green fluorescent protein with the unique properties
September 7, 2018
Researchers from the Biophotonics lab of IBCH RAS (Anastasia Mamontova, Konstantin Lukyanov and Alexey Bogdanov) designed a new green fluorescent protein that combines high fluorescence brightness and short fluorescence lifetime. They used a semi-rational protein evolution approach. Their collaborators from Bach Institute of Biochemistry and Semenov Institute of Physical Chemistry helped with the time-resolved fluorescence analysis (FLIM) that allowed characterizing the physical properties of this perspective probe. Research has recently been published in the Scientific Reports.
- science news Antibiotic from the bear's mouth
September 5, 2018
Scientists from the Laboratory of biocatalysis developed a new microfluidics-based ultrahigh-throughput technology for the “deep functional profiling” of microbial communities and used it to search for bacteria producing new antibiotics in the microbiome of the Siberian bear's oral cavity. This methodology allowed them not only to find the antibiotic amicoumacin, elucidating the mechanisms of its biosynthesis and self-resistance, but also to investigate the spectrum of its activity at the level of various bacterial communities. The results published in PNAS will find numerous applications in the field of antibiotic discovery and will help to solve the problem of antibiotic resistance.
- science news Visit of Delegation of Ministry of Science, Technology and Space of Israel
September 5, 2018
- science news Spider venom may help to stop neuronal death
August 20, 2018
Venoms of spiders and wasps contain acylpolyamines that act as high-affinity blockers of ionotropic receptors for glutamate, the main excitatory neurotransmitter in the human central nervous system (CNS). The first representative of acylpolyamines, argiopin from the venom of the orb-weaver spider Argiope lobata, was discovered in 1986 by Eugene Grishin’s team at IBCh RAS. Here, an international team of scientists, including a researcher from IBCh RAS, has used cryo-electron microscopy (cryo-EM) to determine the first atomic structure of an argiopin-glutamate receptor complex. This structure will help to design new drugs for treatment of neurodegenerative diseases. The study is published in Neuron.
- science news Fast and safe: new reversibly switchable fluorescent proteins for live-cell nanoscopy
July 10, 2018
Russian scientists together with colleagues from Sweden and the USA developed red fluorescent tags that are safe for nanoscopy in living cells. This work was funded by a grant from the Russian Science Foundation (RSF), and the results are published in Nature Methods journal.
- conferences 12th INTERNATIONAL CONFERENCE “BIOCATALYSIS.FUNDAMENTALS & APPLICATIONS” “BIOCATALYSIS-2019”
Dear colleagues, The Lomonosov Moscow State University and RAS institutes, including IBCH RAS, is planning to convene a traditional biannual 12 th International Conference "BIOCATALYSIS-2019" in June, 24–28, 2019. Conference will be convened on board a ship cruising via the route St. Petersburg – Valaam – Kizhi – St. Petersburg. More info is available at http://bc2019.org/.
- science news Scientific School for young scientists «Structural biology: main problems and approaches to their solution»
June 6 (This event is over)
Dear colleagues! The Scientific School is devoted to the latest achievements and methods in the field of structural research will be held at the IBCh RAS on Thursday, 6 June 2019. The scientific program of the School includes lectures by leading scientists working in various fields of molecular biology and representing the basic structural methods, namely, X-ray Crystallography, Cryo-Electron Microscopy, NMR-spectroscopy and computer modeling.
- science news "Molecular Brain" seminar
April 16 (This event is over)
The seminar is timed to the birthday of academician Eugene Grishin and will take place on April 16 at 14:00 in the Hall of Academic Council. Members of the Department of Molecular Neurobiology created by Eugene, will give talks on their present work. Everyone is cordially invited.
- science news Microscopic Imaging of Epigenetic Landscape - A Universal Platform to Study Epigenetic Changes at Single Cell Level
February 15 (This event is over)
- science news "Molecular Brain" seminar
January 22 (This event is over)
The seminar will take place on January 22 at 16:00 in the Minor hall. Professor Leonard Khiroug from the University of Helsinki (Finland) will talk about the "awake microscopy" methodology utilized for high-resolution brain imaging. Everyone is cordially invited.
- science news Lecture by Prof. Zhang Shuguang «The QTY Code: A tool for designing detergent-free membrane proteins»
December 24, 2018 (This event is over)
Prof. Zhang Shuguang from MIT will deliver a lecture entitled «The QTY Code: A tool for designing detergent-free membrane proteins». Date and time: Mon 24 December 2018 15:00. Location: Conference hall at 3rd floor BON IBCh.
- science news Lecture by Prof. Igor Roninson: «CDK8/19: a druggable mediator of transcriptional reprogramming»
December 17, 2018 (This event is over)
Prof. Igor Roninson from University of South Carolina will deliver a lecture entitled «CDK8/19: a druggable mediator of transcriptional reprogramming». Date and time: Mon 17 December 2018 11:00. Location: Conference hall at 3rd floor BON IBCh.
- science news Christmas meeting on neuroscience
December 13, 2018 (This event is over)
The meeting will take place on December 13 at 11:00 in the Minor hall. Talks will be presented by scientists from Russia, Canada, Finland, and Germany; the program is available on the IBCh website. Everyone is cordially invited.
- science news Russian-Israeli Mini-Symposium on Molecular Neurobiology
November 19, 2018 (This event is over)
The symposium will take place on November 19 at 10:00 in the Minor hall. Talks will be presented by scientists from Russia and Israel; the program is available on the IBCh website. Everyone is cordially invited.
- science news Marcus Conrad lecture "Ferroptosis: mechanisms and pharmacological amenability"
October 15, 2018 (This event is over)
Monday, October 15th, 15:00, Small Hall, Marcus Conrad (Institute of Developmental Genetics, Helmholtz Zentrum München) will give a talk "Ferroptosis: mechanisms and pharmacological amenability".