Lindoldhamine can activate the human ASIC3 channel
Researchers from the Laboratory of Neuroreceptors and Neuroregulators (group leader - Sergei Kozlov) found alkaloid lindoldhamine in the leaves of the noble laurel, which can activate the human ASIC3 channel at physiological pH. They reported that acidification of the extracellular medium is not essential for the opening of this channel. Molecules, closely related to the structure of lindolhamine, are produced in the human body during the inflammation and can also activate and alter the functioning of acid-sensitive channels. Regulation of the intracellular synthesis pathways of these endogenous molecules can be a new therapeutic strategy for a novel therapeutic strategy for treatment of pain and inflammation.
28 марта 2018 года