Human SLURP proteins suppress the growth of epithelial cancer cells
Nicotinic acetylcholine receptors (nAChRs) take part in neurotransmission and control the homeostasis of epithelial cells. Group of bioengineering of neuromodulators and neuroreceptors headed by Ekaterina Lyukmanova, Ph.D., studies the influence of human SLURP proteins on the nAChRs in epithelium. In their recent research, published in the British Journal of Pharmacology, investigators proved that SLURPs inhibit the growth of epithelial cancer cells of four carcinomas of epithelial origin, and described the underlying mechanisms. These results show the prospects of implementation of the SLURP proteins for the therapy of epithelial tumours.
15 марта 2018 года