Russ. J. Bioorganic Chem., 2002, 28(4):263-268

Induction of antimeningitis immunity by synthetic peptides: III. Immunoactive synthetic fragments of the NspA protein from Neisseria meningitidis

Four potentially immunoactive peptide fragments of the NspA protein from the outer membrane of the Neisseria meningitidis bacterium were synthesized in order to create a synthetic vaccine against meningococcal infection by the serogroup B bacterium. Mice of various lines were immunized with free peptides nonconjugated with a protein carrier. All the synthetic peptides were shown to induce the production of the antipeptide antibodies in mice. A peptide capable of inducing a decrease in the number of bacteria in blood and the protection of infected animals from death was found in the experiments on the protection of the animals infected with two strains of the Neisseria meningitidis serogroup B.

Koroev DO, Oboznaya MB, Zhmak MN, Volkova TD, Titova MA, Kotelnikova OV, Lakhtina OE, Volpina OM, Nesmeyanov VA, Alliluev AP, Ivanov VT

IBCH: 1395
Ссылка на статью в журнале: http://link.springer.com/10.1023/A:1019559521699
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