Nucleosides Nucleotides Nucleic Acids, 2000, 19(1012):1967-1976

Large-scale solid-phase preparation of 3′-unprotected trinucleotide phosphotriesters - Precursors for synthesis of trinucleotide phosphoramidites

The approach to large-scale solid-phase synthesis of 3′-unprotected trinucleotide phosphotriesters has been developed. The trinucleotides have been synthesized in 5 g scale by phosphotriester approach using CPG with pore size 70A. Total yield of target products was 75-90%. The molar extinctions of trinucleotides at various wavelengths were calculated; The experimental UV-spectra of trinucleotides show a good agreement with theoretical ones. The trinucleotides synthesized were used for synthesis of trinucleotide phosphoramidites - Synthons for generation of DNA/peptide libraries.

IBCH: 1637
Ссылка на статью в журнале: https://www.tandfonline.com/doi/full/10.1080/15257770008045471
Кол-во цитирований на 02.2024: 17
Информация пока не проверена модераторами