Bioorg Khim, 2000, 26(12):926-932

Synthetic peptide constructs on the basis of immunoactive fragments of the A22 strain \pl of the foot-and-mouth disease virus

Peptide constructs consisting of 44-53 aa were synthesized on the basis of sequences 135-159, 170-190 and 197-213 of VP j from the foot-and-mouth disease A22 strain. Immunogenic and protective properties of the peptide constructs were studied in guinea pigs and mice of three lines. The constructs were shown to induce higher levels of antibodies and exhibit higher protective effects than the separate peptides. The most active among the peptides studied was the construct involving the VP] fragments 135-160 and 170-190: it protected pigs from the experimental infection by the foot-and-mouth disease virus.

Kuprianova MA, Zhmak MN, Koroev DO, Chepurkin AV, Volpina OM, Ivanov VT

IBCH: 1966
Кол-во цитирований на 11.2023: 5
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