Cryst. Rep, 2002, 47(4):629-634

Three-dimensional structure of the Arg32His mutant of the human tumor necrosis factor determined at 2.5 Å resolution from X-ray data for a twin crystal

The three-dimensional structure of the Arg32His mutant of the human tumor necrosis factor (TNF-α) was established at 2.5 Å resolution by the molecular replacement method. The crystals of the mutant belong to sp. gr. R3. The specimen has a hemihedral twinning fraction of approximately one half with the twin law corresponding to an additional twofold axis along the a- or b-axis of the crystal lattice. The model analysis of interactions between functionally important loop 29-36 of the mutant and the receptors p55 and p75 was performed. © 2002 MAIK "Nauka/Interperiodica".

Afonin PV, Fokin AV, Shingarova LN, Korobko VG, Tsygannik IN, Artemev IV, Pletnev SV, Pangborn W, Duax WL, Pletnev VZ

IBCH: 5957
Ссылка на статью в журнале: http://link.springer.com/10.1134/1.1496062
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