Bioorg Khim, 2015, 41(6):664-668

Interaction of Arenicin-1 with C1q Protein

Это дубликат статьи: «Interaction of arenicin-1 with C1q protein»

The interaction between arenicin-1, that is an antimicrobial peptide from polychaeta Arenicola marina, and human complement system protein C1q was studied using enzyme-linked receptor sorbent assay and ELISA. We revealed that arenicin-1 and C1q form complex that is stable in high ionic strength condition 0.5 M NaCl. The ability of C1q to interact with arenicin-1 is comparable with the binding activity of C1q towards another antimicrobial peptide, porcine cathelicidin protegrin-1, which has a similar spatial arrangement with arenicin-1. Namely, both arenicin-1 and protegrin-1 form cystine-stabilized antiparallel β-hairpin structure.

Berlov MN, Umnyakova ES, Leonova TS, Milman BL, Krasnodembskaya AD, Ovchinnikova TV, Kokryakov VN

IBCH: 6774
Ссылка на статью в журнале: http://elibrary.ru/item.asp?doi=10.7868/S0132342315060032
Кол-во цитирований на 03.2024: 2
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