Bull Exp Biol Med, 2015, 159(4):541-545

Suppression of ITGB4 Gene Expression in PC-3 Cells with Short Interfering RNA Induces Changes in the Expression of β-Integrins Associated with RGD-Receptors

We studied the effect of transfection of PC-3 prostate cancer cells with a plasmid encoding shRNA complimentary to a fragment of integrin β4 (ITGB4). The results attest to considerable changes in the transcriptome of transfected cells. For instance, compensatory changes in the expression of integrin family genes were found.

Knyazev EN, Nyushko KM, Alekseev BY, Samatov TR, Shkurnikov MY

IBCH: 8253
Ссылка на статью в журнале: http://link.springer.com/10.1007/s10517-015-3011-9
Кол-во цитирований на 10.2023: 14
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