Bioorg Khim, 2004, 30(2):146-150

Activation of the RIG-I gene, coding for DEXH/D-protein in infection of RH cells by tick-borne encephalitis virus

It was demonstrated by subtractive hybridization that the infection of a human embryonic kidney cell line with tick-borne encephalitis virus causes an approximately tenfold transcription activation of the RIG-1 gene, which encodes a protein of the DExH/D-box-containing RNA helicase family. A possible involvement of the protein in antiviral cell systems is discussed. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 2; see also http://www.maik.ru.

Monastyrskaia GS, Kostina MB, Filiukova OB, Protopopova EV, Konovalova SN, Kachko AV, Nikolaev LG, Loktev VB, Sverdlov ED

IBCH: 1512
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