FEBS Lett, 1999, 462(12):205-210

Factors important for fusogenic activity of peptides: Molecular modeling study of analogs of fusion peptide of influenza virus hemagglutinin

Nine analogs of fusion peptide of influenza virus hemagglutinin whose membrane perturbation activity has been thoroughly tested [Murata et al. (1992) Biochemistry 31, 1986-1992; Murata et al. (1993) Biophys. J. 64, 724- 734] were characterized by molecular modeling techniques with the aim of delineating any specific structural and/or hydrophobic properties inherent in peptides with fusogenic activity. It was shown that, regardless of characteristics common to all analogs (peripheral disposition at the water- lipid interface, amphiphilic nature, α-helical structure, etc.), only fusion active peptides reveal a specific 'tilted oblique-oriented' pattern of hydrophobicity on their surfaces and a certain depth of penetration to the non-polar membrane core. The conclusion was reached that these factors are among the most important for the specific destabilization of a bilayer, which is followed by membrane fusion.

IBCH: 1803
Ссылка на статью в журнале: http://doi.wiley.com/10.1016/S0014-5793%2899%2901505-7
Кол-во цитирований на 11.2023: 47
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