Peptides, 2002, 23(5):903-910

Family of hemorphins: Co-relations between amino acid sequences and effects in cell cultures

Hemorphins, i.e. endogenous fragments of β-globin chain segment (32-41) LVVYPWTQRY(F) suppress the growth of transformed murine fibroblasts L929 cell culture, the effect is due to cytotoxicity and inhibition of cell proliferation. The contribution of cytotoxicity depends on the presence of Leu32: VV-hemorphins, except VV-hemorphin-4, exhibit cytotoxicity significantly higher than respective LVV-hemorphins. Decrease of cell number induced by hemorphins depend on the extent of N- and C-terminal degradation of hemorphins: VV-hemorphins in most cases are more active than LVV-, V-hemorphins, and hemorphins. In the group of VV-hemorphins the activity of VV-hemorphin-5 (valorphin) is significantly higher than of VV-hemorphin-7, VV-hemorphin-6, and VV-hemorphin-4, meaning that the presence of C-terminal Gln is important for suppressing of cell number. The amino acid sequence VVYPWTQ corresponding to valorphin was identified as important for manifestation of the both cytotoxic and antiproliferative effects. © 2002 Published by Elsevier Science Inc.

Blishchenko EY, Sazonova OV, Kalinina OA, Yatskin ON, Philippova MM, Surovoy AY, Karelin AA, Ivanov VT

IBCH: 1979
Ссылка на статью в журнале: http://linkinghub.elsevier.com/retrieve/pii/S0196978102000177
Кол-во цитирований на 11.2023: 43
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