J Labelled Compd, 1999, 42(7):663-672

Synthesis of labelled oxylipins: Leukotriene A4and 8-epi-prostaglandin F(2α)

Tritiated leukotriene A4and 8-epi-prostaglandin F(2α) methyl esters were prepared from the corresponding acetylenic precursors by selective reduction with tritium gas to provide a probe for the metabolite identification of these oxylipins. Partially deactivated Pd-catalysts were prepared from commercial products and their composition was optimized to achieve the better selectivity. A micro-method for the saponification of labelled oxylipins methyl esters was used.

Shevchenko VP, Nagaev IY, Myasoedov NF, Guy A, Durand T, Vidal A, Vidal JP, Rossi JC, Bezuglov VV

IBCH: 2462
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