Endovanilloids as differentiation inducers for mammalian cells

Endocannabinoids and endovanilloids encompass a group of lipid neuro- and immunomodulators. By chemical structure they are conjugates of ethanolamine or dopamine with various fatty (usually polyunsaturated) acids. Sometimes, 15S-HPETE and leukotriene B4are also termed endovalilloids by their ability to activate the vanilloid channel TRPV1. All of these substances are synthesized in mammals, as well as in more primitive organisms like freshwater hydra. Endovanilloid action on cell proliferation and differentiation heavily depends on the concentration and includes proliferation stimulation, apoptosis and differentiation modulation. Depending on the molecule structure, the last action could be significantly different: anandamide inhibits neural precursor and keratinocyte differentiation, and the endovanilloids with dopamine, tyramine, norepinephrine and 3-O-methyldopamine residues after a twoweek- long treatment induce neurite outgrowth in PC12 and C6 cells with a shift towards neuronal and astrocytic marker expression, accordingly. The observed differentiation of PC12 and C6 is reversible and occurs via the GPR55 receptor.

IBCH: 3482
Кол-во цитирований на 09.2023: 0
Данные статьи проверены модераторами 2017-10-01