Russ. J. Bioorganic Chem., 2010, 36(4):456-460

Synthesis and properties of myelopeptides possessing differentiating activity

Bone marrow peptides Phe-Arg-Pro-Arg-Ile-Met-Thr-Pro (MP-4) and Val-Asp-Pro-Pro (MP-6) have been synthesized y the classical and solid-phase methods of peptide chemistry, and their differentiatingactivity has been studied on leukemia cell ines HL-60 and K-562. It has been shown that both peptides induce the terminal differentiation of leukemic blasts; however, their echanisms of action are different. © Pleiades Publishing, Ltd., 2010.

Fonina LA, Kudryavtseva EV, Bespalova HD, Efremov MA, Mikhailova AA, Kirilina ESA

IBCH: 459
Ссылка на статью в журнале: http://link.springer.com/10.1134/S1068162010040035
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