Synthesis and properties of myelopeptides possessing differentiating activity
Bone marrow peptides Phe-Arg-Pro-Arg-Ile-Met-Thr-Pro (MP-4) and Val-Asp-Pro-Pro (MP-6) have been synthesized y the classical and solid-phase methods of peptide chemistry, and their differentiatingactivity has been studied on leukemia cell ines HL-60 and K-562. It has been shown that both peptides induce the terminal differentiation of leukemic blasts; however, their echanisms of action are different. © Pleiades Publishing, Ltd., 2010.