An enzymatic transglycosylation of purine bases

An enzymatic transglycosylation of purine heterocyclic bases employing readily available natural nucleosides or sugar-modified nucleosides as donors of the pentofuranose fragment and recombinant nucleoside phosphorylases as biocatalysts has been investigated. An efficient enzymatic method is suggested for the synthesis of purine nucleosides containing diverse substituents at the C6 and C2 carbon atoms. The glycosylation of N6-benzoyladenine and N2-acetylguanine and its O6-derivatives is not accompanied by deacylation of bases. Copyright © Taylor & Francis Group, LLC.

Roivainen J, Elizarova T, Lapinjoki S, Mikhailopulo IA, Esipov RS, Miroshnikov AI

IBCH: 529
Ссылка на статью в журнале: https://www.tandfonline.com/doi/full/10.1080/15257770701506343
Кол-во цитирований на 01.2024: 15
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