Chembiochem, 2003, 4(23):147-154

Polyglycine II nanosheets: Supramolecular antivirals?

Tetraantennary peptides [glycinen-NHCH2]4C can form stable noncovalent structures by self-assembly through intermolecular hydrogen bonding. The oligopeptide chains assemble as polyglycine II to yield submicron-sized, flat, one-molecule-thick sheets. Attachment of α-N-acetylneuraminic acid (Neu5Acα) to the terminal glycine residues gives rise to water-soluble assembled glycopeptides that are able to bind influenza virus multivalently and inhibit adhesion of the virus to cells 103-fold more effectively than a monomeric glycoside of Neu5Acα. Another antiviral strategy based on virus-promoted assembly of the glycopeptides was also demonstrated. Consequently, the self-assembly principle offers new perspectives on the design of multivalent antivirals.

Tuzikov AB, Chinarev AA, Gambaryan AS, Oleinikov VA, Klinov DV, Matsko NB, Kadykov VA, Ermishov MA, Demin IV, Demin VV, Rye PD, Bovin NV

IBCH: 5339
Ссылка на статью в журнале: http://doi.wiley.com/10.1002/cbic.200390025
Кол-во цитирований на 12.2023: 52
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