Appl Organomet Chem, 2009, 23(9):370-374

Novel types of boronated chlorin e6 conjugates via 'click chemistry'

Conjugates of chlorin e6 with closo-dodecaborate and cobalt bis(dicarbollide) anions were synthesized for the first time in high yields using the advanced 'click' methodology. In vitro study on A549 human lung adenocarcinoma cells revealed that the synthesized boronated conjugates are able to penetrate and accumulate in cancer cells, but their intracellular concentration is not sufficient for effective photodynamic and boron neutron capture therapy of cancer. © 2009 John Wiley & Sons, Ltd.

Bregadze VI, Semioshkin AA, Laskova JN, Berzina MY, Lobanova IA, Sivaev IB, Grin MA, Titeev RA, Brittal DI, Ulybina OV, Chestnova AV, Ignatova AA, Feofanov AV, Mironov AF

IBCH: 5496
Ссылка на статью в журнале: http://doi.wiley.com/10.1002/aoc.1521
Кол-во цитирований на 03.2024: 45
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