Russ. J. Bioorganic Chem., 1998, 24(3):166-172

cDNA cloning of three new homeobox-containing genes of the Anf class from human, chicken, and newt

On the basis of the analysis of the cDNA of three new homeobox-containing genes from human, chicken, and newt, a new class of homeobox genes Anf is characterized homologous to the Xanf-1 gene from Xenopus laevis, earlier cloned by us. These genes may be largely involved in the specification of embryonic subdivisions in the forebrain region of the embryo. The homeodomains of the proteins encoded by these genes differ greatly in primary structure from all previously described homeobox genes. The high variability of the homeodomain sequences of the proteins of this class imply their rapid evolution. © 1998 MAHK Hayka/Interperiodica Publishing.

Kazanskaya OV, Ermakova GV, Pannese M, Lukyanov SA, Boncinelli E, Zaraisky AG

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