FEBS Lett, 1998, 426(3):373-376

Endogenous tumour necrosis factor-alpha sensitise melanoma cells to glucosaminylmuramyl dipeptide

Flow cytometry was used to demonstrate that cultured human melanoma BRO cells expressed membrane-bound tumour necrosis factor-alpha (TNF-α) and were able to release TNF-α upon treatment with glucosaminylmuramyl dipeptide (GMDP). The released TNF-α was shown to prime melanoma cells, previously unable to respond to GMDP by increasing expression of melanoma-associated antigens, making them sensitive to GMDP treatment.

Valyakina TI, Komaleva RL, Petrova EE, Malakhov AA, Shamborant OG, Andronova TM, Nesmeyanov VA

IBCH: 5636
Ссылка на статью в журнале: http://doi.wiley.com/10.1016/S0014-5793%2898%2900376-7
Кол-во цитирований на 11.2023: 6
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