FEBS Lett, 1986, 201(2):237-245

Pig kidney Na+,K+-ATPase. Primary structure and spatial organization

cDNAs complementary to pig kidney mRNAs coding for α- and β-subunits of Na+,K+-ATPase were cloned and sequenced. Selective tryptic hydrolysis of the α-subunit within the membrane-bound enzyme and tryptic hydrolysis of the immobilized isolated β-subunit were also performed. The mature α- and β-subunits contain 1016 and 302 amino acid residues, respectively. Structural data on the peptides from extramembrane regions of the α-subunit and on glycopeptides of the β-subunit underlie a model for the transmembrane arrangement of Na+,K+-ATPase polypeptide chains. (Na++ K+)-ATPase α-Subunit β-Subunit cDNA nucleotide sequence Primary structure Glycopeptide Transmembrane arrangement. © 1986.

Ovchinnikov YA, Modyanov NN, Broude NE, Petrukhin KE, Grishin AV, Arzamazova NM, Aldanova NA, Monastyrskaya GS, Sverdlov ED

IBCH: 6224
Ссылка на статью в журнале: http://doi.wiley.com/10.1016/0014-5793%2886%2980616-0
Кол-во цитирований на 02.2024: 166
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