J Labelled Compd, 2008, 51(8):303-307

A new chemical method of synthesis of modified nucleoside [ 32P]phosphates

A simple method of chemical phosphorylation for modified nucleosides with [32P]orthophosphoric acid in the presence of BrCN is described. The yields of 5′-[32P]nucleoside monophosphates achieved are 50-65% at nominal specific radioactivities of ca. 1000 Ci/mmol. The mechanism of phosphorylation in the presence of heterocyclic amines is studied. Copyright © 2008 John Wiley & Sons, Ltd.

Yanvarev DV, Shirokova EA, Kukhanova MK, Skoblov YS

IBCH: 712
Ссылка на статью в журнале: http://doi.wiley.com/10.1002/jlcr.1522
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