Science, 1992, 256(5057):665-667

DNA hydrolyzing autoantibodies

A DNA-nicking activity was detected in the sera of patients with various autoimmune pathologies and was shown to be a property of autoantibodies. The DNA hydrolyzing activity, which was purified by affinity and high-performance liquid chromatography, corresponded in size to immunoglobulin M (IgM) and IgG and had a positive response to antibodies to human IgG. The DNA hydrolyzing autoantibodies were stable to acid shock and yielded a DNA degradation pattern that was different from that of deoxyribonuclease (DNase) I and blood DNase.

Shuster AM, Gololobov GV, Kvashuk OA, Bogomolova AE, Smirnov IV, Gabibov AG

IBCH: 7230
Ссылка на статью в журнале: http://www.sciencemag.org/cgi/doi/10.1126/science.1585181
Кол-во цитирований на 01.2024: 374
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