Structure, 2007, 15(9):1099-1104

Cryo-EM Study of the Pseudomonas Bacteriophage φKZ

The φKZ virus is one of the largest known bacteriophages. It infects Pseudomonas aeruginosa, which is frequently pathogenic in humans, and, therefore, has potential for phage therapy. The φKZ virion consists of an ∼1450 Å diameter icosahedral head and an ∼2000 Å long contractile tail. The structure of the φKZ tail has been determined using cryo-electron microscopy. The φKZ tail is much longer than that of bacteriophage T4. However, the helical parameters of their contractile sheaths, surrounding their tail tubes, are comparable. Although there is no recognizable sequence similarity between the φKZ and T4 tail sheath proteins, they are similar in size and shape, suggesting that they evolved from a common ancestor. The φKZ baseplate is significantly larger than that of T4 and has a flatter shape. Nevertheless, φKZ, similar to T4, has a cell-puncturing device in the middle of its baseplate. © 2007 Elsevier Ltd. All rights reserved.

Fokine A, Battisti AJ, Bowman VD, Efimov AV, Kurochkina LP, Chipman PR, Mesyanzhinov VV, Rossmann MG

IBCH: 981
Ссылка на статью в журнале: http://linkinghub.elsevier.com/retrieve/pii/S096921260700281X
Кол-во цитирований на 10.2023: 54
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