Дубовский Пётр Викторович

Образование

Период обученияСтрана, городУчебное заведениеДополнительная информация
1978–1984 СССР, Москва МИФИ диплом с отличием
1986–1989 СССР, Москва Институт Тонкой Химической Технологии им. Ломоносова М.В. кандидат химических наук
1994–1995 Япония, Кобэ Университет Кобэ стажировка

Научные интересы

Поли-ионные пептиды, структура и взаимодействие с липидными и био-мембранами.

Гранты и проекты

ПериодДополнительная информация
2001–2001 РФФИ:Структура и топология белка-предшественника ферредоксина в мембранах оболочки хлоропластов
2002–2004 РФФИ:Структурно-функциональное изучение пептида слияния из гемагглютинина вируса гриппа 
2007–2009 РФФИ: Изучение мембранных полипептидов с использованием липидных наночастиц.
2013–2015 РФФИ: Взаимосвязь пространственная структура - химический сдвиг в ЯМР для кардиотоксинов кобр.

Избранные публикации

  1. Dubovskii PV, Ignatova AA, Volynsky PE, Ivanov IA, Zhmak MN, Feofanov AV, Efremov RG (2018). Improving therapeutic potential of antibacterial spider venom peptides: coarse-grain molecular dynamics guided approach. Future Med Chem 10 (19), 2309–2322
  2. Dubovskii PV, Dubinnyi MA, Volynsky PE, Pustovalova YE, Konshina AG, Utkin YN, Arseniev AS, Efremov RG (2017). Impact of membrane partitioning on the spatial structure of an S-type cobra cytotoxin. J Biomol Struct Dyn  (0), 1–16
  3. Thien TV, Anh HN, Trang NTT, Trung PV, Khoa NC, Osipov AV, Dubovskii PV, Ivanov IA, Arseniev AS, Tsetlin VI, Utkin YN (2017). Low-molecular-weight compounds with anticoagulant activity from the scorpion Heterometrus laoticus venom. Dokl Biochem Biophys 476 (1), 316–319
  4. Dubovskii PV, Dubinnyi MA, Konshina AG, Kazakova ED, Sorokoumova GM, Ilyasova TM, Shulepko MA, Chertkova RV, Lyukmanova EN, Dolgikh DA, Arseniev AS, Efremov RG (2017). Structural and Dynamic Portraits of Recombinant and Native Cytotoxin I from Naja oxiana: How Close Are They? Biochemistry 56 (34), 4468–4477
  5. Thien TV, Anh HN, Trang NTT, Trung PV, Khoa NC, Osipov AV, Dubovskii PV, Ivanov A, Arseniev S, Tsetlin I, Utkin YN (2017). Low-Molecular Compounds with Anticoagulant Activity from Scorpion Heterometrus loaticus Venom. Dokl Biochem Biophys 476 (4), 476–479
  6. Shulepko MA, Lyukmanova EN, Shenkarev ZO, Dubovskii PV, Astapova MV, Feofanov AV, Arseniev AS, Utkin YN, Kirpichnikov MP, Dolgikh DA (2017). Towards universal approach for bacterial production of three-finger Ly6/uPAR proteins: Case study of cytotoxin I from cobra N. oxiana. Protein Expr Purif 130 (0), 13–20
  7. Dubovskii PV, Vassilevski AA, Kozlov SA, Feofanov AV, Grishin EV, Efremov RG (2015). Latarcins: Versatile spider venom peptides. Cell Mol Life Sci 72 (23), 4501–4522
  8. Dubovskii PV, Utkin YN (2015). Antiproliferative activity of cobra venom cytotoxins. Curr Top Med Chem 15 (7), 638–648
  9. Dubovskii PV, Vorontsova OV, Utkin YN, Arseniev AS, Efremov RG, Feofanov AV (2015). Cobra cytotoxins: Determinants of antibacterial activity. MENDELEEV COMMUN 25 (1), 70–71
  10. Дубовский ПВ, Уткин ЮН (2014). Цитотоксины кобр: структурная организация и антибактериальная активность. Acta Naturae 6 (3), 12–19
  11. Кузнецов АС, Дубовский ПВ, Воронцова ОВ, Феофанов АВ, Ефремов РГ (2014). Взаимодействие линейных катионных пептидов с фосфолипидными мембранами и полимерами сиаловой кислоты. 79 (5), 583–594583–594
  12. Babailov SP, Dubovskii PV, Zapolotsky EN (2014). Paramagnetic lanthanides as magnetic resonance thermo-sensors and probes of molecular dynamics: Holmium-DOTA complex. Polyhedron 79 (0), 277–283
  13. Dubovskii PV, Utkin YN (2014). Cobra cytotoxins: structural organization and antibacterial activity. Acta Naturae 6 (3), 11–8
  14. Kuznetsov AS, Dubovskii PV, Vorontsova OV, Feofanov AV, Efremov RG (2014). Interaction of linear cationic peptides with phospholipid membranes and polymers of sialic acid. Biochemistry (Mosc) 79 (5), 459–468
  15. Dubovskii PV, Utkin YN (2014). Cobra cytotoxins: Structural organization and antibacterial activity. Acta Naturae 6 (22), 11–18
  16. Dubovskii PV, Konshina AG, Efremov RG (2014). Cobra cardiotoxins: Membrane interactions and pharmacological potential. Curr Med Chem 21 (3), 270–287
  17. Konshina AG, Dubovskii PV, Efremov RG (2012). Structure and dynamics of cardiotoxins. Curr Protein Pept Sci 13 (6), 570–584
  18. Dubovskii PV (2012). Unusual titration of the membrane-bound artificial hemagglutinin fusion peptide. Eur Biophys J 41 (12), 1077–1084
  19. Semenova AA, Chugunov AO, Dubovskii PV, Chupin VV, Volynsky PE, Boldyrev IA (2012). The role of chain rigidity in lipid self-association: Comparative study of dihexanoyl- and disorbyl-phosphatidylcholines. Chem Phys Lipids 165 (4), 382–386
  20. Dubovskii PV, Vassilevski AA, Samsonova OV, Egorova NS, Kozlov SA, Feofanov AV, Arseniev AS, Grishin EV (2011). Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin. FEBS J 278 (22), 4382–4393
  21. Dubovskii PV, Vassilevski AA, Slavokhotova AA, Odintsova TI, Grishin EV, Egorov TA, Arseniev AS (2011). Solution structure of a defense peptide from wheat with a 10-cysteine motif. Biochem Biophys Res Commun 411 (1), 14–18
  22. Dubovskii PV, Volynsky PE, Polyansky AA, Karpunin DV, Chupin VV, Efremov RG, Arseniev AS (2008). Three-dimensional structure/hydrophobicity of latarcins specifies their mode of membrane activity. Biochemistry 47 (11), 3525–3533
  23. Vassilevski AA, Kozlov SA, Zhmak MN, Kudelina IA, Dubovskii PV, Shatursky OY, Arseniev AS, Grishin EV (2007). Synthetic analogues of antimicrobial peptides from the venom of the Central Asian spider Lachesana tarabaevi. Russ. J. Bioorganic Chem. 33 (4), 376–382
  24. Dubovskii PV, Volynsky PE, Polyansky AA, Chupin VV, Efremov RG, Arseniev AS (2006). Spatial structure and activity mechanism of a novel spider antimicrobial peptide. Biochemistry 45 (35), 10759–10767
  25. Dubinnyi MA, Lesovoy DM, Dubovskii PV, Chupin VV, Arseniev AS (2006). Modeling of31P-NMR spectra of magnetically oriented phospholipid liposomes: A new analytical solution. Solid State Nucl Magn Reson 29 (4), 305–311
  26. Dubovskii PV, Lesovoy DM, Dubinnyi MA, Konshina AG, Utkin YN, Efremov RG, Arseniev AS (2005). Interaction of three-finger toxins with phospholipid membranes: Comparison of S- and P-type cytotoxins. Biochem J 387 (3), 807–815
  27. Feofanov AV, Sharonov GV, Dubinnyi MA, Astapova MV, Kudelina IA, Dubovskii PV, Rodionov DI, Utkin YN, Arseniev AS (2004). Comparative study of structure and activity of cytotoxins from venom of the cobras naja oxiana, naja kaouthia, and naja haje. Biochemistry (Mosc) 69 (10), 1148–1157
  28. Dubovskii PV, Zhmak MN, Maksaev GI, Arseniev AS (2004). A new water-soluble analogue of the fusion peptide of influenza virus hemagglutinin: Synthesis and properties. Russ. J. Bioorganic Chem. 30 (2), 196–198
  29. Dubovskiǐ PV, Zhmak MN, Maksaev GI, Arsenev AS (2004). New water-soluble analog of the fusion peptide of influenza virus hemagglutinin: synthesis and properties. Bioorg Khim 30 (2), 221–223
  30. Alexeev TA, Dergousova NI, Shibanova ED, Azeeva EA, Kryukova EV, Balashova TA, Dubovskii PV, Arseniev AS, Tsetlin VI (2003). 5-Fluorotryptophan-Containing N-Terminal Domain of the α-Subunit of the Torpedo californica Acetylcholine Receptor: Preparation in Escherichia coli and19F NMR Study. Russ. J. Bioorganic Chem. 29 (4), 351–357
  31. Alekseev TA, Dergousova NI, Shibanova ED, Azeeva EA, Kriukova EV, Balashova TA, Dubovskiǐ PV, Aesenev AS, Tsetlin VI (2003). 5-fluoro-tryptophan-containing N-terminal domain of the alpha-subunit of the Torpedo californica acetylcholine receptor: preparation in E. coli and 19F NMR study. Bioorg Khim 29 (4), 384–390
  32. Dubovskii PV, Lesovoy DM, Dubinnyi MA, Utkin YN, Arseniev AS (2003). Interaction of the P-type cardiotoxin with phospholipid membranes. 270 (9), 2038–2046
  33. Efremov RG, Volynsky PE, Nolde DE, Dubovskii PV, Arseniev AS (2002). Interaction of cardiotoxins with membranes: A molecular modeling study. Biophys J 83 (1), 144–153
  34. Utkin YN, Dubovskii PV, Dubinnyi MA, Zharavin VA, Simonova TN, Barsukov LI, Arseniev AS (2001). The Naja oxiana venom cytotoxin II spin-labeled at Lys35 for the EPR study of its interaction with phospholipid membranes. Bioorg Khim 25 (12), 930–932
  35. Dubinnyi MA, Dubovskii PV, Utkin YN, Simonova TN, Barsukov LI, Arseniev AS (2001). An ESR Study of the Cytotoxin II Interaction with Model Membranes. Russ. J. Bioorganic Chem. 27 (2), 84–94
  36. Iwadate M, Asakura T, Dubovskii PV, Yamada H, Akasaka K, Williamson MP (2001). Pressure-dependent changes in the structure of the melittin α-helix determined by NMR. J Biomol NMR 19 (2), 115–124
  37. Dubinnyi MA, Dubovskii PV, Utkin YN, Simonova TN, Barsukov LI, Arseniev AS (2001). An ESR study of the cytotoxin II interaction with model membranes. Bioorg Khim 27 (2), 112–113
  38. Dubovskii PV, Dementieva DV, Bocharov EV, Utkin YN, Arseniev AS (2001). Membrane binding motif of the P-type cardiotoxin. J Mol Biol 305 (1), 137–149
  39. Orekhov VY, Dubovskii PV, Yamada H, Akasaka K, Arseniev AS (2000). Pressure effect on the dynamics of an isolated α-helix studied by15N-1H NMR relaxation. J Biomol NMR 17 (3), 257–263
  40. Dubovskii PV, Li H, Takahashi S, Arseniev AS, Akasaka K (2000). Structure of an analog of fusion peptide from hemagglutinin. Protein Sci 9 (4), 786–798
  41. Kalbitzer HR, Görler A, Li H, Dubovskii PV, Hengstenberg W, Kowolik C, Yamada H, Akasaka K (2000). 15N and 1H NMR study of histidine containing protein (HPr) from Staphylococcus carnosus at high pressure. Protein Sci 9 (4), 693–703
  42. Utkin YN, Dubovskii PV, Dubinnyi MA, Zharavin VA, Simonova TN, Barsukov LI, Arseniev AS (1999). The Naja oxiana venom cytotoxin II spin-labeled at Lys35 for the EPR study of its interaction with phospholipid membranes. Russ. J. Bioorganic Chem. 25 (12), 828–829
  43. Efremov RG, Nolde DE, Volynsky PE, Chernyavsky AA, Dubovskii PV, Arseniev AS (1999). Factors important for fusogenic activity of peptides: Molecular modeling study of analogs of fusion peptide of influenza virus hemagglutinin. FEBS Lett 462 (12), 205–210
  44. Lurie E, Kaplun A, Vassilenko I, Dubovskii P, Shvets V (1995). Interaction of N-(2-hydroxybenzyl)-ω-amino carbonic acids, novel amphipathic fatty acid derivatives, with membrane: partition coefficients. BIOCHIM BIOPHYS ACTA 1235 (2), 256–262