Подразделение было расформировано в 2017 году.

Отдел «Научно-инновационный центр Технопарк»

«Научно-инновационный центр Технопарк» (далее – Технопарк) является научно-исследовательским подразделением ИБХ РАН и создан для активизации научно-инновационной деятельности Института, повышения эффективности и конкурентоспособности Института в области фундаментальной и прикладной науки. В задачи подразделения входит:

  1. создание инфраструктуры для проведения инновационных научно-исследовательских и опытно-конструкторских работ (НИОКР) в Институте, ориентированных на последующее прикладное использование полученных результатов;
  2. организация выполнения сервисных работ для научных подразделений ИБХ РАН на льготных условиях с целью расширения спектра имеющихся в Институте возможностей по проведению работ научного и научно-технического профиля;
  3. привлечение партнеров и потенциальных потребителей наукоемкой продукции для организации и финансирования совместных инновационно-прикладных проектов;
  4. организация коллективного пользования высокотехнологичным научным оборудованием с целью повышения эффективности его использования и развития приборной базы ИБХ.
Ф.И.О.ДолжностьКонтакты
Фрадков Аркадий Федорович, к. х. н.с.н.с.arc@ibch.ru+7(495)988-40-83#733
Мусаткина Елена Алексеевна, к. б. н.с.н.с.lenam14@yandex.ru
Барсова Екатерина Владимировна, к. б. н.н.с.katia@ibch.ru+7(495)988-40-83#724
Вагнер Лора Лоуренсовна, к. б. н.н.с.lorawagner@evrogen.ru+7(495)988-40-83#736
Матвеева Надежда Константиновнаинженерluk.officemanager@gmail.com

Ранее здесь работали:

Шагин Дмитрий Алексеевич, к. б. н.с.н.с.shagdim@evrogen.ru

Избранные публикации

  1. Kuzmenkov AI, Nekrasova OV, Peigneur S, Tabakmakher VM, Gigolaev AM, Fradkov AF, Kudryashova KS, Chugunov AO, Efremov RG, Tytgat J, Feofanov AV, Vassilevski AA (2018). K1.2 channel-specific blocker from Mesobuthus eupeus scorpion venom: Structural basis of selectivity. Neuropharmacology 143 (0), 228–238
  2. Egorov ES, Merzlyak EM, Shelenkov AA, Britanova OV, Sharonov GV, Staroverov DB, Bolotin DA, Davydov AN, Barsova E, Lebedev YB, Shugay M, Chudakov DM (2015). Quantitative profiling of immune repertoires for minor lymphocyte counts using unique molecular identifiers. J Immunol 194 (12), 6155–6163
  3. Ignatov KB, Barsova EV, Fradkov AF, Blagodatskikh KA, Kramarova TV, Kramarov VM (2014). A strong strand displacement activity of thermostable DNA polymerase markedly improves the results of DNA amplification. Biotechniques 57 (2), 81–87
  4. Klementyeva NV, Shirmanova MV, Serebrovskaya EO, Fradkov AF, Meleshina AV, Snopova LB, Prodanets NN, Lukyanov SA, Zagaynova EV (2013). In vivo bioluminescence imaging of tumor cells using optimized firefly luciferase luc2. Sovrem Tekhnologii Med 5 (3), 6–13
  5. Pletnev VZ, Pletneva NV, Lukyanov KA, Souslova EA, Fradkov AF, Chudakov DM, Chepurnykh T, Yampolsky IV, Wlodawer A, Dauter Z, Pletnev S (2013). Structure of the red fluorescent protein from a lancelet (Branchiostoma lanceolatum): A novel GYG chromophore covalently bound to a nearby tyrosine. Acta Crystallogr D Biol Crystallogr 69 (9), 1850–1860
  6. Ryumina AP, Serebrovskaya EO, Shirmanova MV, Snopova LB, Kuznetsova MM, Turchin IV, Ignatova NI, Klementieva NV, Fradkov AF, Shakhov BE, Zagaynova EV, Lukyanov KA, Lukyanov SA (2013). Flavoprotein miniSOG as a genetically encoded photosensitizer for cancer cells. BIOCHIM BIOPHYS ACTA 1830 (11), 5059–5067
  7. Mishina NM, Markvicheva KN, Fradkov AF, Zagaynova EV, Schultz C, Lukyanov S, Belousov VV (2013). Imaging H2O2 microdomains in receptor tyrosine kinases signaling. Methods Enzymol 526 (0), 175–187
  8. Gurskaya NG, Staroverov DB, Zhang L, Fradkov AF, Markina NM, Pereverzev AP, Lukyanov KA (2012). Analysis of alternative splicing of cassette exons at single-cell level using two fluorescent proteins. Nucleic Acids Res 40 (8), e57
  9. Boyarskikh UA, Kondrakhin YV, Yevshin IS, Sharipov RN, Komelkov AV, Musatkina EA, Tchevkina EM, Sukoyan MA, Kolpakov FA, Kashkin KN, Filipenko ML (2011). Prediction of nonsmall cell lung cancer sensitivity to cisplastin and paclitaxel based on marker gene expression. Mol Biol 45 (4), 600–607
  10. Gurskaya NG, Staroverov DB, Fradkov AF, Lukyanov KA (2011). The coding region of far-red fluorescent protein Katushka contains a strong donor splice site. Russ. J. Bioorganic Chem. 37 (3), 380–382
  11. Gurskaia NG, Staroverov DB, Fradkov AF, Lukaposianov KA (2011). [Coding region of far-red fluorescent protein katushka contains a strong donor splice site]. Bioorg Khim 37 (3), 425–428
  12. Kashkin KN, Musatkina EA, Komelkov AV, Sakharov DA, Trushkin EV, Tonevitsky EA, Vinogradova TV, Kopantzev EP, Zinovyeva MV, Kovaleva OV, Arkhipova KA, Zborovskaya IB, Tonevitsky AG, Sverdlov ED (2011). Genes Potentially Associated with Resistance of Lung Cancer Cells to Paclitaxel. Dokl Biochem Biophys 437 (1), 105–108
  13. Bogdanov EA, Shagina I, Barsova EV, Kelmanson I, Shagin DA, Lukyanov SA (2010). Normalizing cDNA libraries. Curr Protoc Mol Biol  (90), Unit 5.12.1–27
  14. Zhang L, Gurskaia NG, Kopantseva EE, Mudrik NN, Vagner LL, Lukianov KA, Chudakov DM (2010). Identification of the amino acid residues responsible for the reversible photoconversion of the monomeric red fluorescent protein TagRFP protein. Bioorg Khim 36 (2), 187–192
  15. Zhang L, Gurskaya NG, Kopantseva YE, Mudrik NN, Vagner LL, Lukyanov KA, Chudakov DM (2010). Identification of the amino acid residues responsible for the reversible photoconversion of the monomeric red fluorescent protein TagRFP. Russ. J. Bioorganic Chem. 36 (2), 179–184
  16. Bogdanova EA, Shagina IA, Mudrik E, Ivanov I, Amon P, Vagner LL, Lukyanov SA, Shagin DA (2009). DSN depletion is a simple method to remove selected transcripts from cDNA populations. Mol Biotechnol 41 (3), 247–253
  17. Anisimova VE, Barsova EV, Bogdanova EA, Lukyanov SA, Shcheglov AS (2009). Thermolabile duplex-specific nuclease. Biotechnol Lett 31 (2), 251–257
  18. Anisimova VE, Shcheglov AS, Bogdanova EA, Rebrikov DV, Nekrasov AN, Barsova EV, Shagin DA, Lukyanov SA (2008). Is crab duplex-specific nuclease a member of the Serratia family of non-specific nucleases? Gene 418 (12), 41–48
  19. Anisimova VE, Rebrikov DV, Shagin DA, Kozhemyako VB, Menzorova NI, Staroverov DB, Ziganshin R, Vagner LL, Rasskazov VA, Lukyanov SA, Shcheglov AS (2008). Isolation, characterization and molecular cloning of Duplex-Specific Nuclease from the hepatopancreas of the Kamchatka crab. BMC Biochem 9 (1), 14
  20. Shcherbo D, Merzlyak EM, Chepurnykh TV, Fradkov AF, Ermakova GV, Solovieva EA, Lukyanov KA, Bogdanova EA, Zaraisky AG, Lukyanov S, Chudakov DM (2007). Bright far-red fluorescent protein for whole-body imaging. Nat Methods 4 (9), 741–746
  21. Merzlyak EM, Goedhart J, Shcherbo D, Bulina ME, Shcheglov AS, Fradkov AF, Gaintzeva A, Lukyanov KA, Lukyanov S, Gadella TWJ, Chudakov DM (2007). Bright monomeric red fluorescent protein with an extended fluorescence lifetime. Nat Methods 4 (7), 555–557
  22. Hosp J, Tashpulatov A, Roessner U, Barsova E, Katholnigg H, Steinborn R, Melikant B, Lukyanov S, Heberle-Bors E, Touraev A (2007). Transcriptional and metabolic profiles of stress-induced, embryogenic tobacco microspores. Plant Mol Biol 63 (1), 137–149
  23. Gurskaya NG, Verkhusha VV, Shcheglov AS, Staroverov DB, Chepurnykh TV, Fradkov AF, Lukyanov S, Lukyanov KA (2006). Engineering of a monomeric green-to-red photoactivatable fluorescent protein induced by blue light. Nat Biotechnol 24 (4), 461–465
  24. Ilina A, Lipkin A, Barsova E, Issaeva M, Leychenko E, Guzev K, Monastyrnaya M, Lukyanov S, Kozlovskaya E (2006). Amino acid sequence of RTX-A's isoform actinoporin from the sea anemone, Radianthus macrodactylus. Toxicon 47 (5), 517–520
  25. Belousov VV, Fradkov AF, Lukyanov KA, Staroverov DB, Shakhbazov KS, Terskikh AV, Lukyanov S (2006). Genetically encoded fluorescent indicator for intracellular hydrogen peroxide. Nat Methods 3 (4), 281–286
  26. Lukyanov KA, Chudakov DM, Fradkov AF, Labas YA, Matz MV, Lukyanov S (2005). Discovery and properties of GFP-like proteins from nonbioluminescent Anthozoa. Methods Biochem Anal 47 (0), 121–138
  27. Yanushevich YG, Shagin DA, Fradkov AF, Shakhbazov KS, Barsova EV, Gurskaya NG, Labas YA, Matz MV, Lukyanov KA, Lukyanov SA (2005). Spectral diversity among members of the green fluorescent protein family in hydroid jellyfish (Cnidaria, Hydrozoa). Russ. J. Bioorganic Chem. 31 (1), 43–47
  28. Bogdanova EA, Barsova EV, Punkova NI, Britanova OV, Shagin DA, Gurskaya NG, Usman NY, Lukyanov SA (2004). A family of genes of multidomain free lectins from a planarian: Structure, expression, and the use as markers for monitoring regeneration. Russ. J. Bioorganic Chem. 30 (6), 566–576
  29. Zavalova LL, Baskova IP, Barsova EV, Snezhkov EV, Akopov SB, Lopatin SA (2004). Recombinant destabilase-lysozyme: Synthesis de novo in E. coli and action mechanism of the enzyme expressed in Spodoptera frugiperda. Biochemistry (Mosc) 69 (7), 776–781
  30. Zhulidov PA, Bogdanova EA, Shcheglov AS, Vagner LL, Khaspekov GL, Kozhemyako VB, Matz MV, Meleshkevitch E, Moroz LL, Lukyanov SA, Shagin DA (2004). Simple cDNA normalization using kamchatka crab duplex-specific nuclease. Nucleic Acids Res 32 (3), e37
  31. Shagin DA, Barsova EV, Yanushevich YG, Fradkov AF, Lukyanov KA, Labas YA, Semenova TN, Ugalde JA, Meyers A, Nunez JM, Widder EA, Lukyanov SA, Matz MV (2004). GFP-like Proteins as Ubiquitous Metazoan Superfamily: Evolution of Functional Features and Structural Complexity. Mol Biol Evol 21 (5), 841–850
  32. Gurskaya NG, Fradkov AF, Pounkova NI, Staroverov DB, Bulina ME, Yanushevich YG, Labas YA, Lukyanov S, Lukyanov KA (2003). A colourless green fluorescent protein homologue from the non-fluorescent hydromedusa Aequorea coerulescens and its fluorescent mutants. Biochem J 373 (2), 403–408
  33. Fradkov AF, Verkhusha VV, Staroverov DB, Bulina ME, Yanushevich YG, Martynov VI, Lukyanov S, Lukyanov KA (2002). Far-red fluorescent tag for protein labelling. Biochem J 368 (1), 17–21
  34. Rebrikov DV, Bulina ME, Bogdanova EA, Vagner LL, Lukyanov SA (2002). Complete genome sequence of a novel extrachromosomal virus-like element identified in planarian Girardia tigrina. BMC Genomics 3 (0),
  35. Rebrikov DV, Bulina ME, Bogdanova EA, Vagner LL, Lukyanov SA (2002). Complete genome sequence of a novel extrachromosomal virus-like element identified in planarian Girardia tigrina. BMC Genomics 3 (0), 15
  36. Barinova I, Zhexembekova M, Barsova E, Lukyanov S, Heberle-Bors E, Touraev A (2002). Antirrhinum majus microspore maturation and transient transformation in vitro. J Exp Bot 53 (371), 1119–1129
  37. Labas YA, Gurskaya NG, Yanushevich YG, Fradkov AF, Lukyanov KA, Lukyanov SA, Matz MV (2002). Diversity and evolution of the green fluorescent protein family. Proc Natl Acad Sci U S A 99 (7), 4256–4261
  38. Terskikh AV, Fradkov AF, Zaraisky AG, Kajava AV, Angres B (2002). Analysis of DsRed mutants: Space around the fluorophore accelerates fluorescence development. J Biol Chem 277 (10), 7633–7636
  39. Yanushevich YG, Staroverov DB, Savitsky AP, Fradkov AF, Gurskaya NG, Bulina ME, Lukyanov KA, Lukyanov SA (2002). A strategy for the generation of non-aggregating mutants of Anthozoa fluorescent proteins. FEBS Lett 511 (13), 11–14
  40. Shagin DA, Barsova EV, Bogdanova EA, Britanova OV, Gurskaya NG, Lukyanov KA, Matz MV, Punkova NI, Usman NY, Kopantzev EP, Salo E, Lukyanov SA (2002). Identification and characterization of a new family of C-type lectin-like genes from planaria Girardia tigrina. Glycobiology 12 (8), 463–472
  41. Gurskaya NG, Fradkov AF, Terskikh A, Matz MV, Labas YA, Martynov VI, Yanushevich YG, Lukyanov KA, Lukyanov SA (2001). GFP-like chromoproteins as a source of far-red fluorescent proteins. FEBS Lett 507 (1), 16–20
  42. Terskikh A, Fradkov A, Ermakova G, Zaraisky A, Tan P, Kajava AV, Zhao X, Lukyanov S, Matz M, Kim S, Weissman I, Siebert P (2000). 'Fluorescent timer': Protein that changes color with time. Science 290 (5496), 1585–1588
  43. Lukyanov KA, Fradkov AF, Gurskaya NG, Matz MV, Labas YA, Savitsky AP, Markelov ML, Zaraisky AG, Zhao X, Fang Y, Tan W, Lukyanov SA (2000). Natural animal coloration can be determined by a nonfluorescent green fluorescent protein homolog. J Biol Chem 275 (34), 25879–25882
  44. Fradkov AF, Chen Y, Ding L, Barsova EV, Matz MV, Lukyanov SA (2000). Novel fluorescent protein from Discosoma coral and its mutants possesses a unique far-red fluorescence. FEBS Lett 479 (3), 127–130
  45. Tarabykin V, Britanova O, Fradkov A, Voss A, Katz LS, Lukyanov S, Gruss P (2000). Expression of PTTG and prc1 genes during telencephalic neurogenesis. Mech Dev 92 (2), 301–304
  46. Bogush ML, Velikodvorskaya TV, Lebedev YB, Nikolaev LG, Lukyanov SA, Fradkov AF, Pliyev BK, Boichenko MN, Usatova GN, Vorobiev AA, Andersen GL, Sverdlov ED (1999). Identification and localization of differences between Escherichia coli and Salmonella typhimurium genomes by suppressive subtractive hybridization. Mol Gen Genet 262 (45), 721–729
  47. Matz MV, Fradkov AF, Labas YA, Savitsky AP, Zaraisky AG, Markelov ML, Lukyanov SA (1999). Fluorescent proteins from nonbioluminescent Anthozoa species. Nat Biotechnol 17 (10), 969–973
  48. Shagin DA, Lukyanov KA, Vagner LL, Matz MV (1999). Regulation of average length of complex PCR product. Nucleic Acids Res 27 (18), e23
  49. Mats MV, Shagin DA, Usman NI, Bogdanova EA, Fradkov AF, Soboleva TA, Lukianov SA (1998). Cloning of region-specific genetic markers of planaria using a new method--ordered differential display. Bioorg Khim 24 (12), 910–915
  50. Matz MV, Shagin DA, Usman NY, Bogdanova EA, Fradkov AF, Soboleva TA, Lukyanov SA (1998). Cloning of region-specific genetic markers of planarian Dugesia tigrina by means of a new method: Ordered differential display. Russ. J. Bioorganic Chem. 24 (12), 808–812
  51. Akopyants NS, Fradkov A, Diatchenko L, Hill JE, Siebert PD, Lukyanov SA, Sverdlov ED, Berg DE (1998). PCR-based subtractive hybridization and differences in gene content among strains of Helicobacter pylori. Proc Natl Acad Sci U S A 95 (22), 13108–13113
  52. Fradkov AF, Lukyanov KA, Matz MV, Diatchenko LB, Siebert PD, Lukyanov SA (1998). Sequence-independent method for in vitro generation of nested deletions for sequencing large DNA fragments. Anal Biochem 258 (1), 138–141
  53. Zavalova L, Lukyanov S, Baskova I, Snezhkov E, Akopov S, Berezhnoy S, Bogdanova E, Barsova E, Sverdlov ED (1996). Genes from the medicinal leech (Hirudo medicinalis) coding for unusual enzymes that specifically cleave endo-ε(γ-Glu)-Lys isopeptide bonds and help to dissolve blood clots. Mol Gen Genet 253 (12), 20–25
  54. Gurskaya NG, Diatchenko L, Chenchik A, Siebert PD, Khaspekov GL, Lukyanov KA, Vagner LL, Ermolaeva OD, Lukyanov SA, Sverdlov ED (1996). Equalizing cDNA subtraction based on selective suppression of polymerase chain reaction: Cloning of Jurkat cell transcripts induced by phytohemaglutinin and phorbol 12-myristate 13-acetate. Anal Biochem 240 (1), 90–97
  55. Fradkov A, Berezhnoy S, Barsova E, Zavalova L, Lukyanov S, Baskova I, Sverdlov ED (1996). Enzyme from the medicinal leech (Hirudo medicinalis) that specifically splits endo-ε(-γ-Glu)-Lys isopeptide bonds: cDNA cloning and protein primary structure. FEBS Lett 390 (2), 145–148
  56. Efimov VA, Buryakova AA, Fradkov AF, Chakhmakhcheva OA (1996). Bacterial synthesis of human calcitonin and miniproinsulin as fusion proteins with the corresponding antisense peptides and metal-binding peptide. Russ. J. Bioorganic Chem. 22 (7), 428–433
  57. Gurskaya NG, Shagin DA, Lukyanov KA, Vagner LL, Shtutman MS, Musatkina EA, Moinova EV, Tatosyan AG, Lukyanov SA, Sverdlov ED (1996). Cloning of the ha-SDGF gene cDNA from a highly metastatic golden hamster cell line by subtractive hybridization. Russ. J. Bioorganic Chem. 22 (6), 368–373
  58. Efimov VA, Kalinkina AL, Fradkov AF, Chakhmakhcheva OG (1996). An artificial gene for human immunoglobulin G1 Fc fragment and its biosynthesis and properties. Russ. J. Bioorganic Chem. 22 (3), 145–150
  59. Efimov VA, Kalinkina AL, Fradkov AF, Chakhmakhcheva OG (1996). Artificial Gene, Biosynthesis, and Properties of Human Immunoglobulin G1 Fc Fragment. Bioorg Khim 22 (3), 173–174
  60. Efimov VA, Fradkov AF, Raskind AB, Khristin MS, Klimov VV, Chakhmakhcheva OG (1994). Expression of the barley psbA gene in Escherichia coli yields a functional in vitro photosystem II protein D1. FEBS Lett 348 (2), 153–157
  61. Reverdatto SV, Beilinson VA, Fradkov AF, Polushin NN, Efimov VA (1991). Plasmid vectors for 'unclonable' DNA constructions.  (24), 306–307
  62. Khlebodarova TM, Karasik GI, Lapteva SE, Matveeva NM, Serov OL, Sverdlov ED, Broude NE, Modyanov NN, Monastyrskaya GS (1988). Chromosomal localization of the gene coding for the β-subunit of Na+,K+-ATPase in the American mink (Mustela vison). FEBS Lett 236 (1), 240–242
  63. Matveeva NM, Khlebodarova TM, Karasik GI, Rubtsov NB, Serov OL, Sverdlov ED, Broude NE, Modyanov NN, Monastyrskaya GS, Ovchinnikov YA (1987). Chromosomal localization of the gene coding for α-subunit of Na+,K+-ATPase in the American mink (Mustela vison). FEBS Lett 217 (1), 42–44

Лукьянов Сергей Анатольевич

  • Москва, ул. Миклухо-Маклая, 16/10 — На карте
  • ИБХ РАН, корп. 54, комн. 636
  • Тел.: +7(499)724-80-66
  • Эл. почта: luk@ibch.ru

Помощник

Матвеева Надежда Константиновна