Дьяченко Игорь Александрович

Кандидат биологических наук


Старший научный сотрудник (Лаборатория биологических испытаний), (Центр коллективного пользования "Биоорганика")

Эл. почта: dyachenko@bibch.ru

Избранные публикации

  1. Dyachenko IA, Belous GI, Skobtsova LA, Zharmukhamedova TY, Palikov VA, Palikova YA, Dyachenko EV, Kalabina EA, Rudenko VB, Andreev YA, Logashina YA, Kozlov SA, Yavorskii AN, Murashev AN (2018). Analgesic Activity of a Polypeptide Modulator of TRPV1 Receptors. PHARM CHEM J 52 (3), 213–215
  2. Esipov RS, Makarov DA, Stepanenko VN, Kostromina MA, Muravyova TI, Andreev YA, Dyachenko IA, Kozlov SA, Grishin EV (2018). Pilot production of the recombinant peptide toxin of Heteractis crispa as a potential analgesic by intein-mediated technology. Protein Expr Purif 145 (0), 71–76
  3. Palikova YA, Zharmukhamedova TY, Palikov VA, Khokhlova ON, Osipova GA, Andreev YA, Logashina YA, Kozlov SA, Yavorskii AN, Murashev AN, DYachenko IA (2018). Analgesic activity of a natural peptide capable of specific binding to purinergic (P2x3) receptors. Farmakol Toksikol 81 (3), 12–14
  4. Dyachenko IA, Palikov VA, Palikova YA, Belous GI, Murashev AN, Andreev YA, Logashina YA, Maleeva EE, Grishin EV, Kozlov SA (2017). Single mutation in peptide inhibitor of TRPV1 receptor changes its effect from hypothermic to hyperthermic level in animals. Russ. J. Bioorganic Chem. 43 (5), 509–516
  5. Terekhov SS, Palikov VA, Palikova YA, Dyachenko IA, Shamborant OG, Smirnov IV, Masson P, Gabibov AG (2017). Application of Tetrameric Recombinant Human Butyrylcholinesterase as a Biopharmaceutical for Amelioration of Symptoms of Acute Organophosphate Poisoning. Bull Exp Biol Med 163 (4), 430–435
  6. Mokrushina YA, Stepanova AV, Palikov VA, Stepanov AV, Belous GI, Dyachenko IA, Knorre VD, Smirnov IV, Gabibov AG (2017). A Study of the Protective Properties of an Antibody-Based Antidote Metabolizing Organophosphorus Pesticide Paraoxon. Bull Exp Biol Med 163 (2), 218–221
  7. Logashina YA, Solstad RG, Mineev KS, Korolkova YV, Mosharova IV, Dyachenko IA, Palikov VA, Palikova YA, Murashev AN, Arseniev AS, Kozlov SA, Stensvåg K, Haug T, Andreev YA (2017). New disulfide-stabilized fold provides sea anemone peptide to exhibit both antimicrobial and TRPA1 potentiating properties. Toxins (Basel) 9 (5),
  8. Logashina YA, Mosharova IV, Korolkova YV, Shelukhina IV, Dyachenko IA, Palikov VA, Palikova YA, Murashev AN, Kozlov SA, Stensvåg K, Andreev YA (2017). Peptide from sea anemone metridium senile affects transient receptor potential ankyrin-repeat 1 (TRPA1) function and produces analgesic effect. J Biol Chem 292 (7), 2992–3004
  9. Rzhevskiy DI, Kravchenko IN, Sadovnikova ES, Rasskazova EA, Novikova NN, Ponomareva TI, Bondarenko DA, Semushina SG, Dyachenko IA, Shayhutdinova ER, Pakhomova IA, Kalabina EA, Zinchenko DV, Bogachuk AP, Azev VN, Lipkin VM, Murashev AN (2017). Preclinical safety studies of the drug with nootropic activity, based on the amide form of the leukocytes differentiation factor fragment. Russian Journal of Biopharmaceuticals 9 (4), 50–56
  10. Skobtsova LA, Dyachenko IA, Andreev YA, Logashina YA, Murashev AN, Grishin EV (2016). Effect of polypeptides from sea anemone Heteractis crispa on the rodent blood pressure, heart rate, and hemostasis. Dokl Biol Sci 470 (1), 228–230
  11. Stepanov A, Belyy A, Kasheverov I, Rybinets A, Dronina M, Dyachenko I, Murashev A, Knorre V, Sakharov D, Ponomarenko N, Tsetlin V, Tonevitsky A, Deyev S, Belogurov A, Gabibov A (2016). Development of a recombinant immunotoxin for the immunotherapy of autoreactive lymphocytes expressing MOG-specific BCRs. Biotechnol Lett 38 (7), 1173–1180
  12. Osmakov DI, Koshelev SG, Andreev YA, Dyachenko IA, Bondarenko DA, Murashev AN, Grishin EV, Kozlov SA (2016). Conversed mutagenesis of an inactive peptide to ASIC3 inhibitor for active sites determination. Toxicon 116 (0), 11–16
  13. Dubinin MV, Astashev ME, Penkov NV, Gudkov SV, Dyachenko IA, Samartsev VN, Belosludtsev KN (2016). Effects of Phospholipase A2Inhibitors on Bilayer Lipid Membranes. J Membr Biol 249 (3), 339–347
  14. Terekhov SS, Smirnov IV, Shamborant OG, Bobik TV, Ilyushin DG, Murashev AN, Dyachenko IA, Palikov VA, Knorre VD, Belogurov AA, Ponomarenko NA, Kuzina ES, Genkin DD, Masson P, Gabibov AG (2016). Chemical Polysialylation and In Vivo Tetramerization Improve Pharmacokinetic Characteristics of Recombinant Human Butyrylcholinesterase-Based Bioscavengers. Acta Naturae 7 (4), 136–41
  15. Terekhov S, Smirnov I, Bobik T, Shamborant O, Zenkova M, Chernolovskaya E, Gladkikh D, Murashev A, Dyachenko I, Palikov V, Palikova Y, Knorre V, Belogurov A, Ponomarenko N, Blackburn GM, Masson P, Gabibov A (2015). A novel expression cassette delivers efficient production of exclusively tetrameric human butyrylcholinesterase with improved pharmacokinetics for protection against organophosphate poisoning. B SOC CHIM BIOL 118 (0), 51–59
  16. Dyachenko IA, Andreev YA, Logashina YA, Murashev AN, Grishin EV (2015). Biological activity of a polypeptide modulator of TRPV1 receptor. Dokl Biol Sci 465 (1), 279–281
  17. Batchu SN, Smolock EM, Dyachenko IA, Murashev AN, Korshunov VA (2015). Autonomic dysfunction determines stress-induced cardiovascular and immune complications in mice. J Am Heart Assoc 4 (5),
  18. Bondarenko DA, Richter VA, Kuligina EV, Koval OA, Fomin AS, Skoblov YS, Dyachenko IA, Kravchenko IN, Sadovnikova EA, Semushina SG, Novikova NI, Turobov VI, Murashev AN (2015). Toxicity studies and pharmacokinetics of lactaptin. Russian Journal of Biopharmaceuticals 7 (2), 40–47
  19. Terekhov SS, Smirnov IV, Shamborant OG, Bobik TV, Ilyushin DG, Murashev AN, Dyachenko IA, Palikov VA, Knorre VD, Belogurov AA, Ponomarenko NA, Kuzina ES, Genkin DD, Masson P, Gabibov AG (2015). Chemical polysialylation and in vivo tetramerization improve pharmacokinetic characteristics of recombinant human butyrylcholinesterase-based bioscavengers. Acta Naturae 7 (4), 136–141
  20. Terekhov SS, Smirnov IV, Shamborant OG, Zenkova MA, Chernolovskaya EL, Gladkikh DV, Murashev AN, Dyachenko IA, Knorre VD, Belogurov AA, Ponomarenko NA, Deyev SM, Vlasov VV, Gabibov AG (2014). Excessive Labeling Technique Provides a Highly Sensitive Fluorescent Probe for Real-time Monitoring of Biodegradation of Biopolymer Pharmaceuticals in vivo. Acta Naturae 6 (4), 54–9
  21. Terekhov SS, Smirnov IV, Shamborant OG, Zenkova MA, Chernolovskaya EL, Gladkikh DV, Murashev AN, Dyachenko IA, Knorre VD, Belogurov AA, Ponomarenko NA, Deyev SM, Vlasov VV, Gabibov AG (2014). Excessive labeling technique provides a highly sensitive fluorescent probe for real-time monitoring of biodegradation of biopolymer pharmaceuticals in vivo. Acta Naturae 6 (23), 54–59
  22. Andreev YA, Kozlov SA, Korolkova YV, Dyachenko IA, Bondarenko DA, Skobtsov DI, Murashev AN, Kotova PD, Rogachevskaja OA, Kabanova NV, Kolesnikov SS, Grishin EV (2013). Polypeptide modulators of TRPV1 produce analgesia without hyperthermia. Mar Drugs 11 (12), 5100–5115
  23. Osmakov DI, Kozlov SA, Andreev YA, Koshelev SG, Sanamyan NP, Sanamyan KE, Dyachenko IA, Bondarenko DA, Murashev AN, Mineev KS, Arseniev AS, Grishin EV (2013). Sea anemone peptide with uncommon β-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity. J Biol Chem 288 (32), 23116–23127
  24. Dyachenko IA, Murashev AN, Andreeva TV, Tsetlin VI, Utkin YN (2013). Analysis of nociceptive effects of neurotoxic phospholipase A2 from Vipera nikolskii venom in mice. J Venom Res 4 (0), 1–4
  25. Ilyushin DG, Smirnov IV, Belogurov AA, Dyachenko IA, Zharmukhamedova TI, Novozhilova TI, Bychikhin EA, Serebryakova MV, Kharybin ON, Murashev AN, Anikienko KA, Nikolaev EN, Ponomarenko NA, Genkin DD, Blackburn GM, Masson P, Gabibov AG (2013). Chemical polysialylation of human recombinant butyrylcholinesterase delivers a long-acting bioscavenger for nerve agents in vivo. Proc Natl Acad Sci U S A 110 (4), 1243–1248
  26. Dubinnyi MA, Osmakov DI, Koshelev SG, Kozlov SA, Andreev YA, Zakaryan NA, Dyachenko IA, Bondarenko DA, Arseniev AS, Grishin EV (2012). Lignan from thyme possesses inhibitory effect on ASIC3 channel current. J Biol Chem 287 (39), 32993–33000
  27. Kozlov SA, Andreev YA, Murashev AN, Skobtsov DI, DYachenko IA, Grishin EV (2009). New polypeptide components from the Heteractis crispa sea anemone with analgesic activity. Russ. J. Bioorganic Chem. 35 (6), 711–719
  28. Dyachenko IA, Murashev AN, Ovchinnikova TV (2008). Peculiarities of neurotropic effects of zervamicins IIA and IIB. Dokl Biochem Biophys 419 (1), 62–64