Каюшин Алексей Львович

Кандидат химических наук


Старший научный сотрудник (Лаборатория биотехнологии), Старший научный сотрудник (Группа синтеза модифицированных нуклеозидов)

Тел.: +7 (495) 3366833

Эл. почта: kaushin@ibch.ru

Избранные публикации

  1. Denisova AO, Tokunova YA, Fateev IV, Breslav AA, Leonov VN, Dorofeeva EV, Lutonina OI, Muzyka IS, Esipov RS, Kayushin AL, Konstantinova ID, Miroshnikov AI, Stepchenko VA, Mikhailopulo IA (2017). The Chemoenzymatic Synthesis of 2-Chloro- and 2-Fluorocordycepins. Synthesis (Stuttg) 49 (21), 4853–4860
  2. Kharitonova MI, Denisova AO, Andronova VL, Kayushin AL, Konstantinova ID, Kotovskaya SK, Galegov GA, Charushin VN, Miroshnikov AI (2017). New modified 2-aminobenzimidazole nucleosides: Synthesis and evaluation of their activity against herpes simplex virus type 1. Bioorg Med Chem Lett 27 (11), 2484–2487
  3. Kharitonova MI, Fateev IV, Kayushin AL, Konstantinova ID, Kotovskaya SK, Andronova VL, Galegov GA, Charushin VN, Miroshnikov AI (2016). Chemoenzymatic Synthesis and Antiherpes Activity of 5-Substituted 4,6-Difluorobenzimidazoles Ribo- and 2′-Deoxyribonucleosides. Synthesis (Stuttg) 48 (3), 394–406
  4. Kayushin A, Demekhina A, Korosteleva M, Miroshnikov A, Azhayev A (2011). Synthesis of biotin-containing phosphoramidite linker with polyether spacer arm. Nucleosides Nucleotides Nucleic Acids 30 (78), 490–502
  5. Yagodkin A, Azhayev A, Roivainen J, Antopolsky M, Kayushin A, Korosteleva M, Miroshnikov A, Randolph J, Mackie H (2007). Improved synthesis of trinucleotide phosphoramidites and generation of randomized oligonucleotide libraries. Nucleosides Nucleotides Nucleic Acids 26 (5), 473–497
  6. Streletskii AV, Kozlova AY, Esipov DS, Kayushin AL, Korosteleva MD, Esipov SE (2005). Determination of oligonucleotide molecular masses by MALDI mass spectrometry. Bioorg Khim 31 (2), 151–158
  7. Streletskii AV, Kozlova AY, Esipov DS, Kayushin AL, Korosteleva MD, Esipov SE (2005). Determination of oligonucleotide molecular masses by MALDI mass spectrometry. Russ. J. Bioorganic Chem. 31 (2), 139–145
  8. Mauriala T, Auriola S, Azhayev A, Kayushin A, Korosteleva M, Miroshnikov A (2004). HPLC electrospray mass spectrometric characterization of trimeric building blocks for oligonucleotide synthesis. J Pharm Biomed Anal 34 (1), 199–206
  9. Petrovskaya LE, Kryukova EA, Kayushin AL, Rodina AV, Moskaleva EY, Korobko VG (2002). Deletion mutants of human granulocyte-macrophage colony-stimulating factor. Bioorg Khim 28 (5), 445–446
  10. Petrovskaya LE, Kryukova EA, Kayushin AL, Rodina AV, Moskaleva EY, Korobko VG (2002). Deletion mutants of human granulocyte-macrophage colony-stimulating factor. Russ. J. Bioorganic Chem. 28 (5), 397–403
  11. Petrovskaya LE, Kryukova EA, Kayushin AL, Korobko VG (2001). Chaperone Caf1M Stabilizes Hybrid Proteins Containing Sequences of F1 Antigen Subunit from Yersinia pestis. Russ. J. Bioorganic Chem. 27 (4), 241–247
  12. Esipov RS, Gurevich AI, Kayushin AL, Korosteleva MD, Belova MA (2001). The dependence of the E. coli gene expression level on the structure of the translation initiation region (TIR). IV. Distal complementary TIR interactions with the mRNA coding region. Bioorg Khim 25 (7), 552–553
  13. Petrovskaya LE, Kryukova EA, Kayushin AL, Korobko VG (2001). Chaperone Caf1M stabilizes hybrid proteins containing sequences of F1 antigen subunit from Yersinia pestis. Bioorg Khim 27 (4), 281
  14. Kayushin A, Korosteleva M, Miroshnikov A (2000). Large-scale solid-phase preparation of 3′-unprotected trinucleotide phosphotriesters - Precursors for synthesis of trinucleotide phosphoramidites. Nucleosides Nucleotides Nucleic Acids 19 (1012), 1967–1976
  15. Esipov RS, Gurevich AI, Kayushin AL, Korosteleva MD, Belova MA (1999). The dependence of the E. coli gene expression level on the structure of the translation initiation region (TIR). IV. Distal complementary TIR interactions with the mRNA coding region. Bioorg Khim 25 (7), 548–553
  16. Esipov RS, Gurevich AI, Kayushin AL, Korosteleva MD, Belova MA (1999). Dependence of the E. coli gene expression level on the structure of the translation initiation region (TIR). IV. Distal complementary TIR interactions with the mRNA coding region. Russ. J. Bioorganic Chem. 25 (7), 487–491
  17. Kayushin A, Korosteleva M, Miroshnikov A, Kosch W, Zubov D, Piel N, Weichel W, Krenz U (1999). A new approach to the synthesis of trinucleotide phosphoramidites - Synthons for the generation of oligonucleotide/peptide libraries. Nucleosides Nucleotides 18 (67), 1531–1533
  18. Patrushev LI, Zykova ES, Kayushin AL, Korosteleva MD, Miroshnikov AI, Bokarew IN, Leontev SG, Koshkin VM, Severin ES (1998). New DNA diagnostic system for detection of factor V leiden. Thromb Res 92 (6), 251–259
  19. Patrushev LI, Zykova ES, Kayushin AL, Korosteleva MD, Miroshnikov AI (1998). A new DNA-diagnostic system for revealing and identifying homozygous and heterozygous point mutations. Russ. J. Bioorganic Chem. 24 (3), 173–178
  20. Shpakovski GV, Proshkin SA, Kayushin AL, Korosteleva MD, Lebedenko EN (1998). Structural and functional characterization of the rpb8+gene of schizosaccharomyces pombe encoding a subunit of RNA polymerases I-III only specific for eukaryotes. Russ. J. Bioorganic Chem. 24 (2), 105–111
  21. Shpakovski GV, Proshkin SA, Kayushin AL, Korosteleva MD, Lebedenko EN (1998). Structural and Functional Characterization of the rpb8+Gene of Schizosaccharomyces pombe Encoding a Subunit of RNA Polymerases I-III only Specific for Eukaryotes. Bioorg Khim 24 (2), 125
  22. Patrushev LI, Zykova ES, Kayushin AL, Korosteleva MD, Miroshnikov AI (1998). A New DNA-diagnostic System for Revealing and Identifying Homozygous and Heterozygous Point Mutations. Bioorg Khim 24 (3), 200
  23. Gurevich AI, Esipov RS, Kayushin AL, Korosteleva MD (1997). Synthesis of Artificial Genes by PCR on a Synthetic Template. Bioorg Khim 23 (6), 495–496
  24. Esipov RS, Gurevich AI, Kayushin AL, Korosteleva MD, Miroshnikov AI, Shevchenko LV, Pluzhnikov KA, Grishin EV (1997). Recombinant Proteins Containing Amino Acid Sequences of Two Ectatomin Chains. Bioorg Khim 23 (12), 952
  25. Gurevich AI, Esipov RS, Kachalina TA, Kayushin AL, Korosteleva MD (1997). Relation between the Expression Level of an Escherichia coli Gene and the Structure of the Transcription Initiation Region (TIR). III. Sites of Complementary Interaction of TIR with 16S rRNA. Bioorg Khim 23 (11), 893–894
  26. Esipov RS, Gurevich AI, Kayushin AL, Korosteleva MD, Miroshnikov AI, Shevchenko LV, Pluzhnikov KA, Grishin EV (1997). Recombinant proteins containing amino acid sequences of two ectatomin chains. Russ. J. Bioorganic Chem. 23 (12), 839–842
  27. Gurevich AI, Esipov RS, Kachalina TA, Kayushin AL, Korosteleva MD (1997). Relation between the expression level of an Escherichia coli gene and the structure of the Transcription Initiation Region (TIR). III. Sites of complementary interaction of TIR with 16S rRNA. Russ. J. Bioorganic Chem. 23 (11), 790–795
  28. Gurevich AI, Esipov RS, Kayushin AL, Korosteleva MD (1997). Synthesis of artificial genes by PCR on a synthetic template. Russ. J. Bioorganic Chem. 23 (6), 457–460
  29. Zykova ES, Patrushev LI, Kayushin AL, Korosteleva MD, Miroshnikov AI, Bokarev IN, Leontev SG, Koshkin VM, Severin ES (1997). New Allele-Specific Primers for Detecting the Leiden Mutation in Exon 10 of the Factor V Gene in Thrombophilia. Bioorg Khim 23 (3), 210
  30. Zykova ES, Patrushev LI, Kayushin AL, Korosteleva MD, Miroshnikov AI, Bokarev IN, Leontev SG, Koshkin VM, Severin ES (1997). New allele-specific primers for detecting the Leiden mutation in exon 10 of the factor V gene in thrombophilia. Russ. J. Bioorganic Chem. 23 (3), 184–189
  31. Kayushin AL, Korosteleva MD, Miroshnikov AI, Kosch W, Zubov D, Piel N (1996). A convenient approach to the synthesis of trinucleotide phosphoramidites-synthons for the generation of oligonucleotide/peptide libraries. Nucleic Acids Res 24 (19), 3748–3755
  32. Gurevich AI, Kachalina TA, Kayushin AL, Korosteleva MD, Maltsev KV, Mirgorodskaya OA, Miroshnikov AI (1996). Recombinant Protein Containing Oligomeric Sequences of Oxytocin. Bioorg Khim 22 (1), 18–19
  33. Gurevich AI, Kachalina TA, Kayushin AL, Korosteleva MD, Maltsev KV, Mirgorodskaya OA, Miroshnikov AI (1996). Recombinant proteins containing oligomeric sequences of oxytocin. Russ. J. Bioorganic Chem. 22 (1), 12–16