
Doxorubicin-Loaded Polyelectrolyte Multilayer Capsules Modified with Antitumor DR5-Specific TRAIL Variant
Carriers providing active targeted delivery of anticancer drugs to tumor cells are promising for cancer chemotherapy. A team of scientists from the IBCh RAS in collaboration with collegues from other Russian Institutes have developed biodegradable polyelectrolyte microcapsules which have been modified with the DR5-B ligand. The latter is a promising recombinant analogue of the cytokine TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), which specifically binds to the DR5 death receptor overexpressed on the tumor (but not normal) cell membrane. In addition, the capsules were loaded with the anticancer drug doxorubicin (DOX) in a subtoxic concentration. The capsules were demonstrated to provide a targeted drug delivery to tumor cells, as well as a synergistic anticancer effect. The results are published in Nanomaterials. Learn more
News 
- Doxorubicin-Loaded Polyelectrolyte Multilayer Capsules Modified with Antitumor DR5-Specific TRAIL Variant
science news
III.29 Carriers providing active targeted delivery of anticancer drugs to tumor cells are promising for cancer chemotherapy. A team of scientists from the Laboratory of protein engineering and the Laboratory of Biomedical Materials IBCh RAS in collaboration with collegues from other Russian Institutes have developed biodegradable polyelectrolyte microcapsules which have been modified with the DR5-B ligand.
- Diversity of structural, dynamic, and environmental effects explain a distinctive functional role of transmembrane domains in the insulin receptor subfamily
science news
II.28 Human InsR, IGF1R, and IRR receptor tyrosine kinases of the insulin receptor subfamily play an important role in signaling pathways for a wide range of physiological processes. Sharing high sequence and structure homology, the receptors differ dramatically in their localization, expression, and functions. A team of scientists from IBСH RAS in cooperation with colleagues from other institutions using the high-peroscopy of high resolution and computer modeling established that the conformational variability of transmembrane domains and their interaction with surrounding lipids differ significantly among representatives of the subfamily.
- Assessment of core-shell nanoparticles surface structure heterogeneity by SAXS contrast variation and ab initio modeling
science news
II.24 A group of scientists from the Laboratory of Molecular Biophysics and the Laboratory of Carbohydrates of the IBH RAS in collaboration with colleagues from the A.V. Shubnikov Institute of Crystallography of the Russian Academy of Sciences and the European Molecular Biology Laboratory (Hamburg) has developed a new approach to the study of the structure of nanoparticles, combining the methods of SAXS and molecular dynamics.
Events 
- "Molecular Brain" seminar, Epilepsy and channelopathies: from molecular mechanisms to the clinic and back
science news
IX.22.22 (This event is over) The seminar will take place on September 22 at 16:00 in the Minor hall. Three presentations will focus on the current understanding of epilepsy and channelopathies and will consider various aspects: molecular and physiological mechanisms, as well as approaches to therapy. Everyone is cordially invited!
- Seminar “Molecular brain”: Allan Kalueff
science news
V.12.22 (This event is over) Seminar “Molecular brain” resumes its work after the long delay caused by pandemic of new coronavirus infection. However, all the people who are liking to listen lectures on-line, can participate via zoom-translation (link). The seminar will be held on the 12th of May at 3 pm in the Small lecture hall (3rd floor, BON, IBCh). Everyone is welcome!