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  Patents

1. Esipov R.S., Stepanenko V.N., Chupova L.A., Gurevich A.I., Miroshnikov A.I. A method for preparation of genetically engineered human glucagon, recombinant plasmid DNA pER-G1 coding hybrid protein capable of autocatalytic cleavage with the formation of human glucagon, and Escherichia coli ER2566/pER-Gl strain producing the target protein. Patent application submitted on 09.01.2007.

2. Esipov R.S., Stepanenko V.N., Chupova L.A., Gurevich A.I., Miroshnikov A.I. A method for preparation of genetically-engineered human epidermal growth factor, recombinant plasmid DNA pER-hEGF coding for a hybrid protein capable of autocatalytic splitting with the formation of human epidermal factor, and Escherichia coli ER2566/pER-hEGF producer of the target protein. Patent application submitted on 05.10.2007.

3. Konstantinova I.D., Esipov R.S., Muravyova T.I., Taran S.A., Verevkina K.N., Gurevich A.I., Feofanov S.A., Miroshnikov A.I. A method for preparation of 1-(b-D-Ribofuranosyl)- 1,2,4-triazole-3-carboxamide (ribavirin). RF Patent no. 2230118, 10.07.2004.

4. Esipov R.S., Gurevich A.I., Miroshnikov A.I. Recombinant plasmid DNA pERPins1 coding for the amino-acid sequence of recombinant human proinsulin and Escherichia coli BL21(des)/pERPins1 strain producer of recombinant human proinsulin . RF Patent no. 2181771, 27.04.2002.

5. Esipov R.S., Gurevich A.I., Miroshnikov A.I., Chuvikovsky D.V. A method for preparation of purine nucleoside phosphorylase, recombinant plasmid DNA pERPUPHOI, and Escherichia coli BL21(des)/pERPUPHO1 strain producer of purine nucleoside phosphorylase). RF Patent no. 2179188, 10.02.2002.

6. Esipov R.S., Gurevich A.I., Miroshnikov A.I., Chuvikovsky D.V. A method for preparation of recombinant uridine phosphorylase, recombinant plasmid DNA pERPUPHO1, and Escherichia coli BL21(des)/pERPUPHO1 strain producer of uridine phosphorylase. RF Patent no. 2177998, 10.01.2002.

7. Esipov R.S., Gurevich A.I., Miroshnikov A.I., Chuvikovsky D.V. A method for preparation of recombinant thymidine phosphorylase, recombinant plasmid DNA pERTPHO1, and Escherichia coli BL21(des)/pERTPHO1 strain producer of thymidine phosphorylase. RF Patent no. 2188234, 27.08.2002.

8. Gurevich A.I., Esipov R.S., Miroshnikov A.I., Kaushin A.L., Shvets S.V., Kostromina T.I. A method for preparation of oxytocin, recombinant plasmid DNA pteilox4 and Escherichia coli BL21(des)/pteilox4 strain producer of oxytocin. RF Patent no.2161200, 27.12.2000.

9. Gurevich A.I., Kachalina T.A., Miroshnikov A.I., Sverdlov E.D., Azhikina T.L., Rostapshov V.M., Esipov R.S., Vulfson A.N., Tikhonov R.V., Kostromina T.I. A method for preparation of recombinant human interleukin-3, recombinant plasmid DNA p3PTEIL3 coding for recombinant human interleukin, and Escherichia coli strain producer of recombinant human interleukin-3. RF Patent no. 2099421, 20.12.1997.


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