Антираковая активность секретируемых пептидов человека SLURP-1 и SLURP-2: молекулярные механизмы и специфичность действия

1 Июля 2017 года — 30 Июня 2022 года

Шулепко М.А. (рук.)

Лаборатория биоинженерии нейромодуляторов и нейрорецепторов

Грант, РНФ

Список публикаций по проекту

  1. Shulepko MA, Bychkov ML, Shlepova OV, Shenkarev ZO, Kirpichnikov MP, Lyukmanova EN (2020). Human secreted protein SLURP-1 abolishes nicotine-induced proliferation, PTEN down-regulation and α7-nAChR expression up-regulation in lung cancer cells. Int Immunopharmacol 82, 106303
  2. Bychkov ML, Shulepko MA, Shlepova OV, Lyukmanova EN, Kirpichnikov MP (2020). Recombinant Analogue of the Human Protein SLURP-1 Inhibits the Growth of Multicellular Spheroids Reconstructed from Carcinoma Cells. Dokl Biochem Biophys 489 (1), 392–395
  3. Shulepko MA, Bychkov ML, Lyukmanova EN, Kirpichnikov MP (2020). Recombinant Analogue of the Human Protein SLURP-1 Inhibits the Growth of U251 MG and A172 Glioma Cells. Dokl Biochem Biophys 493 (1), 211–214
  4. Shulepko MA, Bychkov ML, Shenkarev ZO, Kulbatskii DS, Makhonin AM, Paramonov AS, Chugunov AO, Kirpichnikov MP, Lyukmanova EN (2021). Biochemical basis of skin disease Mal de Meleda: SLURP-1 mutants differently affect keratinocyte proliferation and apoptosis. J Invest Dermatol 141 (9), 2229–2237
  5. Bychkov ML, Shulepko MA, Shlepova OV, Kulbatskii DS, Chulina IA, Paramonov AS, Baidakova LK, Azev VN, Koshelev SG, Kirpichnikov MP, Shenkarev ZO, Lyukmanova EN (2021). SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer. Front Cell Dev Biol 9, 739391
  6. Bychkov ML, Kirichenko AV, Mikhaylova IN, Paramonov AS, Yastremsky EV, Kirpichnikov MP, Shulepko MA, Lyukmanova EN (2022). Extracellular Vesicles Derived from Acidified Metastatic Melanoma Cells Stimulate Growth, Migration, and Stemness of Normal Keratinocytes. Biomedicines 10 (3),
  7. Bychkov ML, Kirichenko AV, Mikhaylova IN, Paramonov AS, Kirpichnikov MP, Shulepko MA, Lyukmanova EN (2022). Extracellular Vesicles Derived from Metastatic Melanoma Cells Transfer α7-nAChR mRNA, Thus Increasing the Surface Expression of the Receptor and Stimulating the Growth of Normal Keratinocytes. Acta Naturae 14 (3), 95–99
  8. Shulepko MA, Bychkov ML, Kirpichnikov MP, Lyukmanova EN (2023). Recombinant SLURP-1 Inhibits Growth and Migration of U251 MG Glioma by Cell Cycle Arrest and Modulation of MAPK and AKT Signaling Pathways. Russ. J. Bioorganic Chem. 49 (4), 768–774
  9. Bychkov M, Shenkarev Z, Shulepko M, Shlepova O, Kirpichnikov M, Lyukmanova E (2019). Water-soluble variant of human Lynx1 induces cell cycle arrest and apoptosis in lung cancer cells via modulation of α7 nicotinic acetylcholine receptors. PLoS One 14 (5), e0217339