18-29-08054

Создание искусственных библиотек кластеров генов биосинтеза лантибиотиков

7 Августа 2018 года — 7 Декабря 2021 года

Смирнов И.В. (рук.)

Лаборатория химии протеолитических ферментов

Грант, РФФИ

Список публикаций по проекту

  1. Terekhov SS, Nazarov AS, Mokrushina YA, Baranova MN, Potapova NA, Malakhova MV, Ilina EN, Smirnov IV, Gabibov AG (2020). Deep Functional Profiling Facilitates the Evaluation of the Antibacterial Potential of the Antibiotic Amicoumacin. Antibiotics (Basel) 9 (4),
  2. Terekhov SS, Mokrushina YA, Nazarov AS, Zlobin A, Zalevsky A, Bourenkov G, Golovin A, Belogurov A, Osterman IA, Kulikova AA, Mitkevich VA, Lou HJ, Turk BE, Wilmanns M, Smirnov IV, Altman S, Gabibov AG (2020). A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding. Sci Adv 6 (26), eaaz9861
  3. Pipiya SO, Mokrushina YA, Gabibov AG, Smirnov IV, Terekhov SS (2020). Selective Eradication of Staphylococcus aureus by the Designer Genetically Programmed Yeast Biocontrol Agent. Antibiotics (Basel) 9 (9), 1–12
  4. Pipiya SO, Terekhov SS, Mokrushina YA, Knorre VD, Smirnov IV, Gabibov AG (2020). Engineering Artificial Biodiversity of Lantibiotics to Expand Chemical Space of DNA-Encoded Antibiotics. Biochemistry (Mosc) 85 (11), 1319–1334
  5. Terekhov SS, Eliseev IE, Ovchinnikova LA, Kabilov MR, Prjibelski AD, Tupikin AE, Smirnov IV, Belogurov AA, Severinov KV, Lomakin YA, Altman S, Gabibov AG (2020). Liquid drop of DNA libraries reveals total genome information. Proc Natl Acad Sci U S A 117 (44), 27300–27306