Монастырская Галина Сергеевна

Личная информация

1962-наст.вр.: старший лаборант, научный сотрудник, ведущий научный сотрудник Института биоорганической химииРАН

Образование

Период обученияСтрана, городУчебное заведениеДополнительная информация
1958–1962 Россия, Москва Московский химический политехникум им. В. И. Ленина Диплом химика
1964–1970 Россия, Москва Московский государственный университет имени М.В. Ломоносова (МГУ), химический факультет Диплом химика
1975 Россия, Москва Институт биоорганической химии им. М. М. Шемякина АН СССР (ИБХ) Присуждена учёная степень кандидата химических наук

Премии и заслуги

 

1981 — Государственная премия СССР
1985 — Орден Трудового Красного Знамени
2001 — Премия Правительства РФ в области науки и техники

Основные научные результаты

 

Основные труды посвящены разработке методов исследования генетического материала, анализу структур и функций генов, развитию теоретических основ современной биотехнологии и получению биотехнологических продуктов для медицины и сельского хозяйства. Руководитель ряда дипломных работ и кандидатских диссертаций. Результаты исследований опубликованы в более чем 200 печатных работах.

Избранные публикации

  1. Bezborodova OA, Nemtsova ER, Gevorkov AR, Boyko AV, Venediktova JB, Alekseenko IV, Kostina MB, Monastyrskaya GS, Sverdlov ED, Khmelevskiy EV, Yakubovskaya RI (2016). Antitumor efficacy of combined gene and radiotherapy in animals. Dokl Biochem Biophys 470 (1), 345–348
  2. Alekseenko IV, Pleshkan VV, Monastyrskaya GS, Kuzmich AI, Snezhkov EV, Didych DA, Sverdlov ED (2016). Fundamentally low reproducibility in molecular genetic cancer research. Russ J Genet 52 (7), 650–663
  3. Zinovyeva MV, Kuzmich AI, Monastyrskaya GS, Sverdlov ED (2016). The role of FOXA subfamily factors in embryonic development and carcinogenesis of the pancreas. Mol. Gen. Microbiol. Virol. 31 (3), 135–142
  4. Vinogradova TV, Chernov IP, Monastyrskaya GS, Kondratyeva LG, Sverdlov ED (2016). Cancer Stem Cells: Plasticity Works against Therapy. Acta Naturae 7 (4), 46–55
  5. Alekseenko IV, Snezhkov EV, Chernov IP, Pleshkan VV, Potapov VK, Sass AV, Monastyrskaya GS, Kopantzev EP, Vinogradova TV, Khramtsov YV, Ulasov AV, Rosenkranz AA, Sobolev AS, Bezborodova OA, Plyutinskaya AD, Nemtsova ER, Yakubovskaya RI, Sverdlov ED (2015). Therapeutic properties of a vector carrying the HSV thymidine kinase and GM-CSF genes and delivered as a complex with a cationic copolymer. J Transl Med 13 (1), 78
  6. Zinovyeva MV, Kostina MB, Monastyrskaya GS, Sass AV, Filyukova OB, Vinogradova TV, Kopantzev EP, Sverdlov ED (2015). Genetic markers for lung and esophagus common precursor cells in human development. Dokl Biochem Biophys 463 (1), 203–208
  7. Vinogradova TV, Chernov IP, Monastyrskaya GS, Kondratyeva LG, Sverdlov ED (2015). Cancer stem cells: Plasticity works against therapy. Acta Naturae 7 (4), 46–55
  8. Kashkin K, Chernov I, Stukacheva E, Monastyrskaya G, Uspenskaya N, Kopantzev E, Sverdlov E (2015). Cancer specificity of promoters of the genes controlling cell proliferation. J Supramol Struct Cell Biochem 116 (2), 299–309
  9. Kashkin KN, Chernov IP, Stukacheva EA, Kopantzev EP, Monastyrskaya GS, Uspenskaya NY, Sverdlov ED (2013). Cancer specificity of promoters of the genes involved in cell proliferation control. Acta Naturae 5 (3), 79–83
  10. Didych DA, Shamsutdinov MF, Smirnov NA, Akopov SB, Monastyrskaya GS, Uspenskaya NY, Nikolaev LG, Sverdlov ED (2013). Human PSENEN and U2AF1L4 genes are concertedly regulated by a genuine bidirectional promoter. Gene 515 (1), 34–41
  11. Kashkin KN, Chernov IP, Stukacheva EA, Kopantzev EP, Monastyrskaya GS, Uspenskaya NY, Sverdlov ED (2013). Cancer specificity of promoters of the genes involved in cell proliferation control. Acta Naturae 5 (18), 79–83
  12. Zinovyeva MV, Monastyrskaya GS, Kopantzev EP, Vinogradova TV, Kostina MB, Sass AV, Filyukova OB, Uspenskaya NY, Sukhikh GT, Sverdlov ED (2010). Identification of some human genes oppositely regulated during esophageal squamous cell carcinoma formation and human embryonic esophagus development. Dis Esophagus 23 (3), 260–270
  13. Kopantzev EP, Monastyrskaya GS, Vinogradova TV, Zinovyeva MV, Kostina MB, Filyukova OB, Tonevitsky AG, Sukhikh GT, Sverdlov ED (2008). Differences in gene expression levels between early and later stages of human lung development are opposite to those between normal lung tissue and non-small lung cell carcinoma. Lung Cancer 62 (1), 23–34
  14. Fushan A, Monastyrskaya G, Abaev I, Sverdlov E (2006). Genomic fingerprinting of Burkholderia pseudomallei and B. mallei pathogens with DNA array based on interspecies sequence differences obtained by subtractive hybridization. Res Microbiol 157 (7), 684–692
  15. Fushan A, Monastyrskaya G, Abaev I, Kostina M, Filyukova O, Pecherskih E, Sverdlov E (2005). Genome-wide identification and mapping of variable sequences in the genomes of Burkholderia mallei and Burkholderia pseudomallei. Res Microbiol 156 (2), 278–288
  16. Monastyrskaya G, Fushan A, Abaev I, Filyukova O, Kostina M, Pecherskih E, Sverdlov E (2004). Genome-wide comparison reveals great inter- and intraspecies variability in B. pseudomallei and B. mallei pathogens. Res Microbiol 155 (9), 781–793
  17. Monastyrskaya GS, Kostina MB, Filyukova OB, Protopopova EV, Konovalova SN, Kachko AV, Nikolaev LG, Loktev VB, Sverdlov ED (2004). The transcription activation of the RIG-I gene encoding the DEXH/D protein in RH cells infected with tick-borne encephalitis virus. Russ. J. Bioorganic Chem. 30 (2), 129–132
  18. Monastyrskaia GS, Kostina MB, Filiukova OB, Protopopova EV, Konovalova SN, Kachko AV, Nikolaev LG, Loktev VB, Sverdlov ED (2004). Activation of the RIG-I gene, coding for DEXH/D-protein in infection of RH cells by tick-borne encephalitis virus. Bioorg Khim 30 (2), 146–150
  19. Gavrilov BG, Monastyrskaia GS, Velikodvorskaia TV, Filiukova OB, Konovalova SN, Kachko AA, Protopopova EV, Nikolaev LG, Loktev VB, Sverdlov ED (2003). Late activation of interferon-induced genes IFI-54k and IFI-56k in human RH cells infected with tick-borne encephalitis virus. Bioorg Khim 29 (2), 175–180
  20. Gavrilov BG, Monastyrskaya GS, Velikodvorskaya TV, Filyukova OB, Konovalova SN, Kachko AA, Protopopova EV, Nikolaev LG, Loktev VB, Sverdlov ED (2003). Late Activation of Interferon-Induced Genes IFI-54K and IFI-56K in Human RH Cells Infected with Tick-borne Encephalitis Virus. Russ. J. Bioorganic Chem. 29 (2), 154–159
  21. Nikiforova NN, Velikodvorskaja TV, Kachko AV, Nikolaev LG, Monastyrskaya GS, Lukyanov SA, Konovalova SN, Protopopova EV, Svyatchenko VA, Kiselev NN, Loktev VB, Sverdlov ED (2002). Induction of alternatively spliced spermidine/spermine N1-acetyltransferase mRNA in the human kidney cells infected by Venezuelan equine encephalitis and tick-borne encephalitis viruses. Virology 297 (2), 163–171
  22. Lavrentieva I, Khil P, Vinogradova T, Akhmedov A, Lapuk A, Shakhova O, Lebedev Y, Monastyrskaya G, Sverdlov ED (1998). Subfamilies and nearest-neighbour dendrogram for the LTRs of human endogenous retroviruses HERV-K mapped on human chromosome 19: Physical neighbourhood does not correlate with identity level. Hum Genet 102 (1), 107–116
  23. Smith CL, Wang D, Broude N, Bukanov N, Monastyrskaya GS, Sverdlov E (1996). Parallel processing in genome mapping and sequencing. Methods 9 (1), 136–144
  24. Volik S, Lebedev Y, Nikolaev L, Shevchenko Y, Vinogradova T, Kopantzev E, Kolesnik T, Monastyrskaya G, Kunz U, Grzeschik KH, Ashworth LK, Lennon G, Sverdlov E (1995). Mapping of transcribed sequences on human chromosome 19. Mitochondrial DNA 6 (1), 13–26
  25. Borodin A, Kopatnzev E, Wagner L, Volik S, Ermolaeva O, Lebedev Y, Monastyrskaya G, Kunz J, Grzeschik KH, Sverdlov E (1995). An arrayed library enriched in hncDNA corresponding to transcribed sequences of human chromosome 19: preparation and analysis. Genet Anal Tech Appl 12 (1), 23–31
  26. Modyanov NN, Petrukhin KE, Sverdlov VE, Grishin AV, Orlova MY, Kostina MB, Makarevich OI, Broude NE, Monastyrskaya GS, Sverdlov ED (1991). The family of human Na,K-ATPase genes ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase. FEBS Lett 278 (1), 91–94
  27. Ushkaryov YA, Monastyrskaya GS, Broude NE, Nikiforova NN, Bessarab DA, Orlova MY, Petrukhin KE, Modyanov NN, Sverdlov ED (1989). Human Na+, K+-ATPase genes. β-Subunit gene family contains at least one gene and one pseudogene. FEBS Lett 257 (2), 439–442
  28. Broude NE, Modyanov NN, Monastyrskaya GS, Sverdlov ED (1989). Advances in Na+,K+-ATPase studies: from protein to gene and back to protein. FEBS Lett 257 (1), 1–9
  29. Sverdlov ED, Bessarab DA, Malyshev IV, Petrukhin KE, Smirnov YV, Ushkaryov YA, Monastyrskaya GS, Broude NE, Modyanov NN (1989). Family of human Na+,K+-ATPase genes Structure of the putative regulatory region of the α+-gene. FEBS Lett 244 (2), 481–483
  30. Sverdlov ED, Akopyanz NS, Petrukhin KE, Broude NE, Monastyrskaya GS, Modyanov NN (1988). Na+, K+-ATPase: Tissue-specific expression of genes coding for α-subunit in diverse human tissues. FEBS Lett 239 (1), 65–68
  31. Khlebodarova TM, Karasik GI, Lapteva SE, Matveeva NM, Serov OL, Sverdlov ED, Broude NE, Modyanov NN, Monastyrskaya GS (1988). Chromosomal localization of the gene coding for the β-subunit of Na+,K+-ATPase in the American mink (Mustela vison). FEBS Lett 236 (1), 240–242
  32. Ogryzko EP, Nikiforov VG, Borodin AM, Danilkovich AV, Monastyrskaia GS (1988). Amino acid substitutions in the beta-subunit of RNA-polymerase from E. coli compensating for mutation-induced damage of the rho termination factors. Bioorg Khim 14 (7), 963–964
  33. Ovchinnikov YA, Monastyrskaya GS, Broude NE, Ushkaryov YA, Melkov AM, Smirnov YV, Malyshev IV, Allikmets RL, Kostina MB, Dulubova IE, Kiyatkin NI, Grishin AV, Modyanov NN, Sverdlov ED (1988). Family of human Na+,K+-ATPase genes Structure of the gene for the catalytic subunit (αIII-form) and its relationship with structural features of the protein. FEBS Lett 233 (1), 87–94
  34. Lisitsyn NA, Monastyrskaya GS, Sverdlov ED (1988). Genes coding for RNA polymerase β subunit in bacteria. Structure/function analysis. 177 (2), 363–369
  35. Sverdlov ED, Broude NE, Sverdlov VE, Monastyrskaya GS, Grishin AV, Petrukhin KE, Akopyanz NS, Modyanov NN, Ovchinnikov YA (1987). Family of Na+, K+-ATPase genes Intra-individual tissue-specific restriction fragment length polymorphism. FEBS Lett 221 (1), 129–133
  36. Sverdlov ED, Monastyrskaya GS, Broude NE, Ushkaryov YA, Allikmets RL, Melkov AM, Smirnov YV, Malyshev IV, Dulobova IE, Petrukhin KE, Grishin AV, Kijatkin NI, Kostina MB, Sverdlov VE, Modyanov NN, Ovchnikov YA (1987). The family of human Na+,K+-ATPase genes No less than five genes and/or pseudogenes related to the α-subunit. FEBS Lett 217 (2), 275–278
  37. Matveeva NM, Khlebodarova TM, Karasik GI, Rubtsov NB, Serov OL, Sverdlov ED, Broude NE, Modyanov NN, Monastyrskaya GS, Ovchinnikov YA (1987). Chromosomal localization of the gene coding for α-subunit of Na+,K+-ATPase in the American mink (Mustela vison). FEBS Lett 217 (1), 42–44
  38. Ovchinnikov YA, Monastyrskaya GS, Broude NE, Allikmets RL, Ushkaryov YA, Melkov AM, Smirnov YV, Malyshev IV, Dulubova IE, Petrukhin KE, Gryshin AV, Sverdlov VE, Kiyatkin NI, Kostina MB, Modyanov NN, Sverdlov ED (1987). The family of human Na+K+-ATPase genes. A partial nucleotide sequence related to the α-subunit. FEBS Lett 213 (1), 73–80
  39. Ovchinnikov YA, Modyanov NN, Broude NE, Petrukhin KE, Grishin AV, Arzamazova NM, Aldanova NA, Monastyrskaya GS, Sverdlov ED (1986). Pig kidney Na+,K+-ATPase. Primary structure and spatial organization. FEBS Lett 201 (2), 237–245
  40. Ovchinnikov YA, Monastyrskaya GS, Guriev SO, Kalinina NF, Sverdlov ED, Gragerov AI, Bass IA, Kiver IF, Moiseyeva EP, Igumnov VN, Mindlin SZ, Nikiforov VG, Khesin RB (1983). RNA polymerase rifampicin resistance mutations in Escherichia coli: Sequence changes and dominance. Mol Gen Genet 190 (2), 344–348
  41. Ovchinnikov YA, Monastyrskaya GS, Gubanov VV, Guryev SO, Salomatina IS, Shuvaeva TM, Lipkin VM, Sverdlov ED (1982). The primary structure ot E. coli RNA porymerase. nucleotide sequence of the rpoC gene and amino acid sequence of the β′-sabunit. Nucleic Acids Res 10 (13), 4035–4044
  42. Ovchinnikov YA, Monastyrskaya GS, Gubanov VV, Lipkin VM, Sverdlov ED, Kiver IF, Bass IA, Mindlin SZ, Danilevskaya ON, Khesin RB (1981). Primary structure of Escherichia coli RNA polymerase nucleotide substitution in the β subunit gene of the rifampicin resistant rpoB255 mutant. Mol Gen Genet 184 (3), 536–538
  43. Shemyakin MF, Chestukhin AV, Dolganov GM, Khodkova EM, Monastyrskaya GS, Sverdlov ED (1980). Leu-enkephalin purification from E. coli cells carrying the plasmid with fused synthetic leu-enkephalin gene. Nucleic Acids Res 8 (24), 6163–6174
  44. Sverdlov ED, Monastyrskaya GS, Poverenny AM, Semin YA, Kolomyitseva EN (1979). A new method of determination of adenine units location in DNA. FEBS Lett 108 (2), 427–428
  45. Ovchinnikov YA, Guryev SO, Krayev AS, Monastyrskaya GS, Skryabin KG, Sverdlov ED, Zakharyev VM, Bayev AA (1979). Primary structure of an EcoRI fragment of λimm434 DNA containing regions cI-cro of phage 434 and cII-O of phage lambda. Gene 6 (3), 235–249
  46. Sverdlov ED, Monastyrskaya GS, Tarabakina NS, Budowsky EI (1976). Reaction of the cytosine nucleus with hydrazine in the presence of bisulphite. FEBS Lett 62 (2), 212–214
  47. Verdlov ED, Monastyrskaya GS, Guskova LI, Levitan TL, Sheichenko VI, Budowsky EI (1974). Modification of cytidine residues with a bisulfite-O-methylhydroxylamine mixture. Biochimica et Biophysica Acta - Section Nucleic Acids And Protein Synthesis 340 (2), 153–165
  48. Sverdlov ED, Monastyrskaya GS, Chestukhin AV, Budowsky EI (1973). The primary structure of oligonucleotides. Partial apurinization as a method to determine the positions of purine and pyrimidine residues. FEBS Lett 33 (1), 15–17
  49. Sverdlov ED, Monastyrskaya GS, Budowsky EI (1972). Determination of the number of cytidine residues in oligonucleotides. FEBS Lett 28 (2), 236–238
  50. Sverdlov ED, Monastyrskaya GS, Budowsky EI, Grachev MA (1972). A novel approach to structural analysis of oligonucleotides. FEBS Lett 28 (2), 231–235
  51. Budowsky EI, Sverdlov ED, Monastyrskaya GS (1972). New method of selective and rapid modification of the cytidine residues. FEBS Lett 25 (1), 201–204
  52. Budowsky EI, Sverdlov ED, Shibaeva RP, Monastyrskaya GS, Kochetkov NK (1971). Mechanism of the mutagenic action of hydroxylamine. III. Reaction of hydroxylamine and O-methylhydroxylamine with the cytosine nucleus. Biochimica et Biophysica Acta - Section Nucleic Acids And Protein Synthesis 246 (2), 300–319