Чернов Игорь Павлович

Кандидат химических наук


Старший научный сотрудник (Лаборатория структуры и функций генов человека)

Тел.: +7 (495) 330-70-29

Эл. почта: igor_ch@ibch.ru

Избранные публикации

  1. Kondratyeva LG, Chernov IP, Zinovyeva MV, Egorov VI, Kopantzev EP, Sverdlov ED (2018). Heterogeneous Expression of Embryonal Development Master Regulator SOX9 in Patients with Pancreatic Cancer. Dokl Biochem Biophys 481 (1), 208–211
  2. Kashkin KN, Chernov IP, Didych DA, Sverdlov ED (2017). Construction of a combinatorial library of chimeric tumor-specific promoters. Biotechniques 63 (3), 107–116
  3. Kondratyeva LG, Kashkin KN, Chernov IP, Stukacheva EA, Dydich DA, Kopantzev EP, Sverdlov ED (2017). PCNA: A Constitutive Human Promoter for Gene Expression for Functional Studies and Therapeutic Applications. Mol. Gen. Microbiol. Virol. 32 (3), 137–140
  4. Kondratyeva LG, Didych DA, Chernov IP, Kopantzev EP, Stukacheva EA, Vinogradova TV, Sverdlov ED (2017). Dependence of expression of regulatory master genes of embryonic development in pancreatic cancer cells on the intracellular concentration of the master regulator PDX1. Dokl Biochem Biophys 475 (1), 259–263
  5. Kondratyeva LG, Chernov IP, Zinovyeva MV, Kopantzev EP, Sverdlov ED (2017). Expression of master regulatory genes of embryonic development in pancreatic tumors. Dokl Biochem Biophys 475 (1), 250–252
  6. Zinovyeva MV, Kostina MB, Chernov IP, Kondratyeva LG, Sverdlov ED (2016). KLF5, a new player and new target in the permanently changing set of pancreatic cancer molecular drivers. Russ. J. Bioorganic Chem. 42 (6), 606–611
  7. Kondratyeva LG, Sveshnikova AA, Grankina EV, Chernov IP, Kopantseva MR, Kopantzev EP, Sverdlov ED (2016). Downregulation of expression of mater genes SOX9, FOXA2, and GATA4 in pancreatic cancer cells stimulated with TGFβ1 epithelial–mesenchymal transition. Dokl Biochem Biophys 469 (1), 257–259
  8. Vinogradova TV, Chernov IP, Monastyrskaya GS, Kondratyeva LG, Sverdlov ED (2016). Cancer Stem Cells: Plasticity Works against Therapy. Acta Naturae 7 (4), 46–55
  9. Alekseenko IV, Snezhkov EV, Chernov IP, Pleshkan VV, Potapov VK, Sass AV, Monastyrskaya GS, Kopantzev EP, Vinogradova TV, Khramtsov YV, Ulasov AV, Rosenkranz AA, Sobolev AS, Bezborodova OA, Plyutinskaya AD, Nemtsova ER, Yakubovskaya RI, Sverdlov ED (2015). Therapeutic properties of a vector carrying the HSV thymidine kinase and GM-CSF genes and delivered as a complex with a cationic copolymer. J Transl Med 13 (1), 78
  10. Kondratyeva LG, Vinogradova TV, Chernov IP, Sverdlov ED (2015). Master transcription regulators specifying cell-lineage fates in development as possible therapeutic targets in oncology. Russ J Genet 51 (11), 1049–1059
  11. Kondratyeva LG, Vinogradova TV, Chernov IP, Sverdlov ED (2015). Master Transcription Regulators Specifying Cell-Lineage Fates in Development As Possible Therapeutic Targets in Oncology. Genetika 51 (11), 1221–1233
  12. Vinogradova TV, Chernov IP, Monastyrskaya GS, Kondratyeva LG, Sverdlov ED (2015). Cancer stem cells: Plasticity works against therapy. Acta Naturae 7 (4), 46–55
  13. Kashkin K, Chernov I, Stukacheva E, Monastyrskaya G, Uspenskaya N, Kopantzev E, Sverdlov E (2015). Cancer specificity of promoters of the genes controlling cell proliferation. J Supramol Struct Cell Biochem 116 (2), 299–309
  14. Shubin AV, Lunina NA, Shedova EN, Roshina MP, Demidyuk IV, Vinogradova TV, Kopantsev EP, Chernov IP, Kostrov SV (2013). Evaluation of the toxic effects evoked by the transient expression of protease genes from human pathogens in HEK293 cells. APPL BIOCHEM MICRO+ 49 (9), 750–755
  15. Kashkin KN, Chernov IP, Stukacheva EA, Kopantzev EP, Monastyrskaya GS, Uspenskaya NY, Sverdlov ED (2013). Cancer specificity of promoters of the genes involved in cell proliferation control. Acta Naturae 5 (3), 79–83
  16. Kashkin KN, Chernov IP, Stukacheva EA, Kopantzev EP, Monastyrskaya GS, Uspenskaya NY, Sverdlov ED (2013). Cancer specificity of promoters of the genes involved in cell proliferation control. Acta Naturae 5 (18), 79–83
  17. Alekseenko IV, Pleshkan VV, Kopantzev EP, Stukacheva EA, Chernov IP, Vinogradova TV, Sverdlov ED (2012). Activity of the Upstream Component of Tandem TERT/Survivin Promoters Depends on Features of the Downstream Component. PLoS One 7 (10), e46474
  18. Sorotokina AN, Chernov IP, Stukacheva EA, Nikolaev LG, Sverdlov ED (2011). Enhancer activity of DNA fragments from the FXYD5-COX7A region of human chromosome 19. Russ. J. Bioorganic Chem. 37 (2), 217–224
  19. Mingaleeva RN, Chernov IP, Kopantzev EP, Zavalova LL, Sass AV, Sverdlov ED (2010). Comparative analysis of herpes simplex virus thymidine kinase gene expression potentiation via HIV-1 Tat-TAR system and cancer-specific promoters in P53(+) and P53(-) cells. Mol Biol 44 (3), 448–453
  20. Mingaleeva RN, Chernov IP, Kopantsev EP, Stukacheva EA, Skaptseva NV, Sverdlov ED (2009). Study of transactivation effect on transcription by Tat-TAR system of human immunodeficiency virus type i (HIV-I) in nonlymphoid cells HEK293 and Calu-1. Mol. Gen. Microbiol. Virol. 24 (2), 56–60
  21. Akopov SB, Chernov IP, Wahlström T, Kostina MB, Klein G, Henriksson M, Nikolaev LG (2008). Identification of recognition sites for Myc/Max/Mxd network proteins by a whole human chromosome 19 selection strategy. Biochemistry (Mosc) 73 (11), 1260–1268
  22. Chernov IP, Stukacheva EA, Akopov SB, Didych DA, Nikolaev LG, Sverdlov ED (2008). A new technique for selective identification and mapping of enhancers within long genomic sequences. Biotechniques 44 (6), 775–784
  23. Akopov SB, Chernov IP, Vetchinova AS, Bulanenkova SS, Nikolaev LG (2007). Identification and mapping of cis-regulatory elements within long genomic sequences. Mol Biol 41 (5), 717–722
  24. Akopov SB, Chernov IP, Bulanenkova SS, Skvortsova YV, Vetchinova AS, Nikolaev LG (2007). Methods for identification of epigenetic elements in mammalian long multigenic genome sequences. Biochemistry (Mosc) 72 (6), 589–594
  25. Chernov IP, Timchenko KA, Akopov SB, Nikolaev LG, Sverdlov ED (2007). Identification of tissue-specific DNA-protein binding sites by means of two-dimensional electrophoretic mobility shift assay display. Anal Biochem 364 (1), 60–66
  26. Nikolaev LG, Akopov SB, Chernov IP, Sverdlow ED (2007). Maps of cis-regulatory nodes in megabase long genome segments are an inevitable intermediate step toward whole genome functional mapping. Curr Genomics 8 (2), 137–149
  27. Nikolaev LG, Akopov SB, Chernov IP, Sverdlov ED (2007). Maps of cis-Regulatory Nodes in Megabase Long Genome Segments are an Inevitable Intermediate Step Toward Whole Genome Functional Mapping. Curr Genomics 8 (2), 137–49
  28. Shaposhnikov SA, Akopov SB, Chernov IP, Thomsen PD, Joergensen C, Collins AR, Frengen E, Nikolaev LG (2007). A map of nuclear matrix attachment regions within the breast cancer loss-of-heterozygosity region on human chromosome 16q22.1. Genomics 89 (3), 354–361
  29. Akopov SB, Ruda VM, Batrak VV, Vetchinova AS, Chernov IP, Nikolaev LG, Bode J, Sverdlov ED (2006). Identification, genome mapping, and CTCF binding of potential insulators within the FXYD5-COX7A1 locus of human Chromosome 19q13.12. Mouse Genome 17 (10), 1042–1049
  30. Vetchinova AS, Akopov SB, Chernov IP, Nikolaev LG, Sverdlov ED (2006). Two-dimensional electrophoretic mobility shift assay: Identification and mapping of transcription factor CTCF target sequences within an FXYD5-COX7A1 region of human chromosome 19. Anal Biochem 354 (1), 85–93
  31. Chernov IP, Akopov SB, Nikolaev LG, Sverdlov ED (2006). Identification and mapping of DNA binding proteins target sequences in long genomic regions by two-dimensional EMSA. Biotechniques 41 (1), 91–96
  32. Chernov IP, Akopov SB, Nikolaev LG (2004). Structure and function of nuclear matrix associated regions (S/MARs). Bioorg Khim 30 (1), 3–14
  33. Chernov IP, Akopov SB, Nikolaev LG (2004). Structure and functions of nuclear matrix associated regions (S/MARs). Russ. J. Bioorganic Chem. 30 (1), 1–11
  34. Chernov IP, Akopov SB, Nikolaev LG, Sverdlov ED (2001). Identification and mapping of nuclear matrix-attachment regions in a one megabase locus of human chromosome 19q13.12: Long-range correlation of S/MARS and gene positions. J Supramol Struct Cell Biochem 84 (3), 590–600
  35. Chernov IP, Polyakov AS, Akopov SB, Nikolaev LG, Azhikina TL, Kostina MB, Sverdlov ED (1999). Identification and human chromosome 19 mapping of a chromosome-specific repeated element binding preferentially to nuclear matrix. Russ. J. Bioorganic Chem. 25 (4), 242–247
  36. Chernov IP, Polyakov AS, Akopov SB, Nikolaev LG, Azhikina TL, Kostina MB, Sverdlov ED (1999). Identification and human chromosome 19 mapping of a chromosome-specific repeated element binding preferentially to nuclear matrix. Bioorg Khim 25 (4), 281
  37. Sverdlov ED, Tsarev SA, Markova SV, Rostapshov VM, Azhikina TL, Chernov IP, Gorbalenya AE, Kolesnikova MS, Romanova LI, Teterina NL, Tolskaya EA, Agol VI (1989). Insertion of short hepatitis virus A amino acid sequences into poliovirus antigenic determinants results in viable progeny. FEBS Lett 257 (2), 354–356
  38. Rostapshov VM, Chernov IP, Azhikina TL, Borodin AM, Sverdlov ED (1989). Effective method for obtaining long nucleotide chains on partially complementary templates Processed bovine γ-interferon gene obtained from human γ-interferon gene. FEBS Lett 249 (2), 379–382
  39. Borodin AM, Danilkovich AV, Allikmets RL, Rostapshov VM, Chernov IP (1988). Nucleotide sequence of of rpoB gene encoding the RNA-polymerase beta-subunit in Pseudomonas putida. Dokl Akad Nauk SSSR 302 (5), 1261–1265
  40. Danilkovich AV, Borodin AM, Allikmets RL, Rostapshov VM, Chernov IP (1988). Nucleotide sequence of the rpoC-gene coding for RNA polymerase beta'-subunit of Pseudomonas putida. Dokl Akad Nauk SSSR 303 (1), 241–245
  41. Borodin AM, Danilkovich AV, Chernov IP, Azhikina TL, Rostapshov VM (1988). Genes coding for RNA polymerase in bacteria. III. The use of modified Sanger's method for sequencing the C-terminal region of rpoB gene, N-terminal region of rpoC gene and intercistron region of RNA polymerase in Pseudomonas putida. Bioorg Khim 14 (9), 1179–1182
  42. Borodin AM, Danilkovich AV, Allikmets RL, Azhikina TL, Chernov IP (1988). Genes coding for RNA-polymerase in bacteria. II. Conservative sites in the central region of the beta-subunit of Pseudomonas putida RNA-polymerase. Bioorg Khim 14 (7), 979–981
  43. Sverdlov ED, Tsarev SA, Krykbaev RA, Chernov IP, Rostapshov VM (1987). trp operon induction during the expression in E. coli of two IFN-γ sequences. FEBS Lett 212 (2), 233–236