Elastic fibers and elastin receptor complex: Neuraminidase-1 takes the center stage
In addition to the "supporting" role, the extracellular matrix (ECM) affects the phenotype and behavior of the cell. The largest structures of ECM are elastic fibers (EF), which are mainly composed of elastin. Elastogenesis is a tightly regulated process involving the sialidase activity of the Neuraminidase-1 (Neu-1), which is part of the elastin receptor. Neu-1 also serves as a sensor of elastin degradation, it is able to regulate the activation of TGF-beta and possibly is involved in remodeling of EFs. The article, published in the journal Matrix Biology, provides an overview of the results of long-term studies of molecular mechanisms of life regulation of elastic fibers, in which Neu-1 plays a key role. A number of important data, in particular, the existence of the membrane-bound form of Neu-1 and its ability to dimerize, was first obtained by the French-Russian research team from the University of Reims and IBCH RAS (Lab. of biomolecular modeling).