The transcription activation of the RIG-I gene encoding the DEXH/D protein in RH cells infected with tick-borne encephalitis virus
It was demonstrated by subtractive hybridization that the infection of a human embryonic kidney cell line with tick-borne encephalitis virus causes an approximately tenfold transcription activation of the RIG-I gene, which encodes a protein of the DEXH/D-box-containing RNA helicase family. A possible involvement of the protein in antiviral cell systems is discussed.