Proc Natl Acad Sci U S A, 1993, 90(24):11460-11462

Strings of contiguous modified pentanucleotides with increased DNA- binding affinity can be used for DNA sequencing by primer walking

Modified oligonucleotides containing 5-methylcytidine and/or 2- aminoadenosine form tighter hybrids with DNA and are, therefore, more efficient primers for DNA sequencing as compared to their natural counterparts. Strings of contiguous modified pentanucleotides can be used for DNA sequencing by primer walking.

Azhikina T, Veselovskaya S, Myasnikov V, Potapov V, Ermolayeva O, Sverdlov E

Лаборатория структуры и функций генов человека, Лаборатория регуляторной транскриптомики

: 10.1073/pnas.90.24.11460
Scopus: 2-s2.0-0027144123
: 8265574
IBCH: 2931
Ссылка на статью в журнале: http://www.pnas.org/cgi/doi/10.1073/pnas.90.24.11460
Кол-во цитирований на 03.2024: 35
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