Transcriptional phenotype of B cells infiltrating lung cancer tumors has been characterized depending on the B-cell receptor isotype expression (IgA/IgG)
An article by researchers from the Institute of Bioorganic Chemistry has been published in Frontiers in Immunology, dedicated to the study of B-lymphocytes infiltrating lung and kidney tumors. For the first time, the scientists demonstrated that in patients with lung adenocarcinoma a subpopulation of memory B cells expressing membrane IgA is characterized by increased expression of FCRL4, PD-1, and RUNX2 — markers of chronic antigen stimulation and functional exhaustion. Analysis of TCGA data showed that a high level of FCRL4 expression is associated with poorer patient survival. The study expands our current understanding of the role of B cells in tumors and may contribute to the development of immunotherapy approaches aimed at restoring B-cell activity.
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