Accumulation of HLA-E-directed KIR+NKG2C+ NK cells is associated with the ex vivo phenotype
Adaptive NK cells coexpressing KIR and NKG2C receptors are promising antitumor effectors. A team of researchers from the Institute of Bioorganic Chemistry used stimulation with a cytomegalovirus peptide presented within the HLA-E molecule to expand such effectors in vitro, and revealed the dependence of the accumulation of adaptive NK cells possessing high HLA-E-directed cytotoxicity on the NK cell phenotype ex vivo.These findings are of interest for the therapeutic use of NK cells, and also contribute to a better understanding of virus-mediated modulation of NK cell population diversity. The study is supported by RSF grant 26-15-00648 and published in the International Journal of Molecular Science.
31 июля