Glucose is an essential source of energy in humans. Over the past decades, consumption of sugar has increased greatly and constitutes a large part of the global energy intake [1]. Currently, overconsumption of sugar is a serious problem around the world and contributes to the high incidence of obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality [1]. As a result, there is an unmet clinical need to clarify the mechanisms of sugar preference and craving and to find means of limiting sugar overconsumption.