The Research Topic titled “Venoms, Animal and Microbial Toxins” is focused on the structural and functional properties of animal derived venoms, plant and microbial toxins, as well as their molecular/cellular targets. It compiles seventeen key research articles and up-to-date reviews in the field to better describe venoms, the structural features of toxins (and derivatives thereof) and their various modes of action, through the analyses of their structural characteristics, structure-function relationship, and pharmacology.