Group of chemistry of natural products

The name "Group of Chemistry of Natural Products" recalls the former name of the Institute (as well as the division at Chemistry Department at MSU). The key areas of the research are total synthesis, study of natural products biosynthesis, development of original  chemical transformations, and medicinal chemistry

Currently, investigation results in the following scientific directions are published:

1) Development of the synthetic approaches towards hasubanan (Eur. J. Org. Chem. 2022, e202200675; J. Org. Chem. 2023, 9737) and Kopsia alkaloids (Synthesis 2024, 56, 346) 

2) Total synthesis and biosynthesis study of the fragmented angucycline antibiotics (Nat. Prod. Rep. 2021, 1506; ChemistrySelect 2021, 11775) 

3) Preparation of the annulated and spirocyclic HIV-1 integrase inhibitors (IJMS 2023, 24, 17354; ChemistrySelect 2024, 9, e202305123)

4) Cycloaddition of imidazol-5-one activated donor-acceptor cyclopropanes with aldehydes (Org. Lett. 2020, 22, 2740; Chem. Heterocycl. Compds. 2020, 56, 1092)

5) C-H activation by means of 1,5-hydride shift and the related processes for preparation of spirocyclic and heterocyclic compounds (Synthesis, 2021, 53, 4689; )

1) Tandem [3,3]-sigmatropic rearrangement (J. Org. Chem. 2023, 9737) for synthesis of hasubanan alkaloids is studied (Eur. J. Org. Chem. 2022, e202200675)

2) Biosynthesis of fragmented angucyclinones is revised (Nat. Prod. Rep. 2021, 1506). A series of the corresponding derivatives is synthesized (ChemistrySelect 2021, 11775) 

3) Screening of Structure-Activity Relationship for inhibitors of post-integrational gap repar of HIV-1 is carried out (IJMS 2023, 24, 17354; ChemistrySelect 2024, 9, e202305123)

4) A new class of donor-acceptor cyclopropanes and original mechanism of their activation are proposed (Org. Lett. 2020, 22, 2740)

5) An approach towards unsymmetric julolidines via 1,5-hydride-shift-triggered cyclization is developed (Synthesis, 2021, 4689)

Andrey Mikhaylov, Ph.D.s. r. f.
Al' Mufti A.M.t. q. - lab. as.
Viktoriya Ikonnikovat. q. - lab. as.

Andrey Mikhaylov

Russia, Moscow, Ul. Miklukho-Maklaya 16/10 — On the map