Human InsR, IGF1R, and IRR receptor tyrosine kinases of the insulin receptor subfamily play an important role in signaling pathways for a wide range of physiological processes. Sharing high sequence and structure homology, the receptors differ dramatically in their localization, expression, and functions. A team of scientists from IBСH RAS in cooperation with colleagues from other institutions using the high-peroscopy of high resolution and computer modeling established that the conformational variability of transmembrane domains and their interaction with surrounding lipids differ significantly among representatives of the subfamily.

A group of scientists from the Laboratory of Molecular Biophysics and the Laboratory of Carbohydrates of the IBH RAS in collaboration with colleagues from the A.V. Shubnikov Institute of Crystallography of the Russian Academy of Sciences and the European Molecular Biology Laboratory (Hamburg) has developed a new approach to the study of the structure of nanoparticles, combining the methods of SAXS and molecular dynamics.

A collaboration of scientists from the Science-Educational center of the IBCh RAS and the Center for Pathophysiology, Infectology and Immunology of the Medical University of Vienna proved that the main allergens from the pollen from trees of the order Fagales, including alder Aln g 1, have the ability to cause Bet v 1-independent sensitization of the immune system in patients living in birch-dominated areas.

The extreme aggressiveness and lethality of many cancer types appeal to the problem of the development of new-generation treatment strategies based on smart materials. The targeted delivery of nanoparticles to specific cancer cell receptors is believed to be such a strategy; however, there are no targeted nano-drugs that have successfully completed clinical trials to date. To meet the challenge, the team of the Laboratory of Molecular Immunology of the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, the Laboratory for Biochemical Research of Carcinogenesis of the Moscow Institute of Physics and Technology, and the Department of Nanobiomedicine of the Sirius University, have developed an alternative method of oncotherapy.

Plants utilize small secreted peptides as important mediators of many processes, from growth and development to response to stress conditions. One of such regulators is the conservative 5 kDa cysteine-rich RALF (Rapid Alkalinization Factor) peptide family, which is widely present in terrestrial plants. RAPID ALKALINIZATION FACTOR (RALFs) are peptides that regulate multiple physiological processes in plants. This peptide family has considerably expanded during land plant evolution, but the role of ancient RALFs in modulating stress responses is unknown

Employing antibody fragments instead of full-length antibodies in antibody-drug conjugates can facilitate accumulation of the therapeutics in the tumor and reduce their side effects. Scientists from the Laboratory of molecular immunology together with colleagues from the Laboratory of cell interactions, the Laboratory of molecular diagnostics at IBCh RAS, and other Russian Institutes have for the first time developed GD2-specific antibody fragment-drug conjugates. Minibody and scFv fragment conjugates with the tubulin-inhibiting drugs MMAE and MMAF manifested strong cytotoxic and cytostatic effects in GD2-positive neuroblastoma and melanoma cell lines.

A group of scientists from the Laboratory of Molecular Design and Synthesis, the Protein Growth and Differentiation Factor Expression Group of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, the Institute of Poliomyelitis and other institutes synthesized a series of compounds based on 5-(perylene-3-ylethynyl)uracil and studied their antiviral properties and mechanism of action. Previous studies of this class of compounds have suggested controversial types of mechanisms of action. Nonetheless providing comparable high activity. The present study showed that, upon irradiation with light, amphiphilic compounds accumulated in cell and viral membranes inhibit the entry of enveloped viruses into the cell.

Curtobacterium is a genus of Gram-positive bacteria within the order Actinomycetales. Some Curtobacterium species are harmful pathogens of agricultural crops such as soybean, dry beans, peas, sugar beet and beetroot, which occur throughout the world. About 200 publicly available genomes of Curtobacterium species, including environmental metagenomic sequences, were inspected for the presence of sequences of possible prophage origin using bioinformatic methods.

One of the challenging tasks of Duplodnaviria taxonomy is the classification of high-ranked taxa, including families and orders. In this study, the team of scientists from the Laboratory of molecular bioengineering IBCh RAS in collaboration with the colleagues from the Limnological Institute analized the evolutionary relationships of conserved viral proteins, representing different viruses, including all classified Duplodnaviria families, using AlphaFold modelling.

The members of the redox biology group and the Laboratory of molecular technologies from the Department of Metabolism and Redox Biology, IBCH RAS, in the collaboration with colleagues from Federal Center of Brain Research and Neurotechnologies, Federal Medical Biological Agency, and Pirogov Russian National Research Medical University, using a well-established model of long-term potentiation, revealed that neuronal oxidative stress affects synaptic plasticity.