• Innovative Contact Lenses with Metal-Organic Frameworks for Glaucoma Treatment science news V.13

    Researchers from the Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Harvard University, Sechenov University, the Pasteur Institute, and other scientific institutions in Russia and abroad have proposed a new method for controlling elevated intraocular pressure, which is a major damaging factor in glaucoma. They have developed a new type of contact lenses that incorporate metal-organic frameworks (MOFs) for the controlled and prolonged release of brimonidine, a medication used to reduce intraocular pressure. This innovation was presented in the high-ranking scientific journal Aggregate, highlighting its innovative nature and potential impact on ophthalmological practice.

  • NMR spectroscopy reveals patterns and thermodynamic parameters of dimerization of β- hairpin antimicrobial peptides in the membrane science news IV.10

    The staff of the Laboratory of structural biology of ion channels and the Science–Educational center for the first time studied the thermodynamics of the dimerization process of a β-hairpin peptide in the membrane-mimicking environment of detergent micelles using the example of the antimicrobial peptide (AMP) capitellacin of the marine polychaete Capitella teleta. The study also describes the mechanism of capitellacin action on bacterial membranes. The results of the work were published in the journal Biomolecules.

  • Human RPF1 and ESF1 in Pre-rRNA Processing and Assembly of Pre-Ribosomal Particles: A Functional Study science news III.6

    Ribosome biogenesis is a sophisticated time-ordered process, which adjusts the protein synthesis rate to consumption of nutrients and external stimuli. It begins with transcription of the ribosomal primary RNA precursor. 13.3 kB 47S (fig.) pre-rRNA processing is coupled with the sequential recruitment of ribosome biogenesis factors and non-coding RNAs as well as ordered coating of rRNA with ~80 ribosomal proteins during formation of the functional 60S and 40S ribosomal subunits.