
Diversity of structural, dynamic, and environmental effects explain a distinctive functional role of transmembrane domains in the insulin receptor subfamily
Human InsR, IGF1R, and IRR receptor tyrosine kinases of the insulin receptor subfamily play an important role in signaling pathways for a wide range of physiological processes. Sharing high sequence and structure homology, the receptors differ dramatically in their localization, expression, and functions. A team of scientists from IBСH RAS in cooperation with colleagues from other institutions using the high-peroscopy of high resolution and computer modeling established that the conformational variability of transmembrane domains and their interaction with surrounding lipids differ significantly among representatives of the subfamily. Thus, the heterogeneous membrane environment should be taken into account in the diverse activation mechanisms of InsR, IGF1R, and IRR. This membrane-mediated control of receptor signaling offers an attractive prospect for the development of new targeted therapies for diseases associated with dysfunction of insulin subfamily receptors. The results are published in the International Journal of Molecular Sciences. Learn more
News 
- Diversity of structural, dynamic, and environmental effects explain a distinctive functional role of transmembrane domains in the insulin receptor subfamily
science news
II.28 Human InsR, IGF1R, and IRR receptor tyrosine kinases of the insulin receptor subfamily play an important role in signaling pathways for a wide range of physiological processes. Sharing high sequence and structure homology, the receptors differ dramatically in their localization, expression, and functions. A team of scientists from IBСH RAS in cooperation with colleagues from other institutions using the high-peroscopy of high resolution and computer modeling established that the conformational variability of transmembrane domains and their interaction with surrounding lipids differ significantly among representatives of the subfamily.
- Assessment of core-shell nanoparticles surface structure heterogeneity by SAXS contrast variation and ab initio modeling
science news
II.24 A group of scientists from the Laboratory of Molecular Biophysics and the Laboratory of Carbohydrates of the IBH RAS in collaboration with colleagues from the A.V. Shubnikov Institute of Crystallography of the Russian Academy of Sciences and the European Molecular Biology Laboratory (Hamburg) has developed a new approach to the study of the structure of nanoparticles, combining the methods of SAXS and molecular dynamics.
- Bet v 1-independent sensitization to major allergens in Fagales pollen: Evidence at the T-cell level
science news
II.13 A collaboration of scientists from the Science-Educational center of the IBCh RAS and the Center for Pathophysiology, Infectology and Immunology of the Medical University of Vienna proved that the main allergens from the pollen from trees of the order Fagales, including alder Aln g 1, have the ability to cause Bet v 1-independent sensitization of the immune system in patients living in birch-dominated areas.
Events 
- "Molecular Brain" seminar, Epilepsy and channelopathies: from molecular mechanisms to the clinic and back
science news
IX.22.22 (This event is over) The seminar will take place on September 22 at 16:00 in the Minor hall. Three presentations will focus on the current understanding of epilepsy and channelopathies and will consider various aspects: molecular and physiological mechanisms, as well as approaches to therapy. Everyone is cordially invited!
- Seminar “Molecular brain”: Allan Kalueff
science news
V.12.22 (This event is over) Seminar “Molecular brain” resumes its work after the long delay caused by pandemic of new coronavirus infection. However, all the people who are liking to listen lectures on-line, can participate via zoom-translation (link). The seminar will be held on the 12th of May at 3 pm in the Small lecture hall (3rd floor, BON, IBCh). Everyone is welcome!