Scientists from IBCh RAS with colleagues from Photobiology Lab (IBP SB RAS) elucidated the structures of Beroe abissycola photoprotein’s chromophore photoinactivation products and proposed a mechanism of the photoinactivation process. The similarity of chemical transformations of photoprotein and GFP-like fluorescent protein chromophores was demonstrated for the first time. The results are published in Organic Letters. The project was funded by the RScF grant № 17-14-01169p.  

Toll-like receptors are the key players of the innate immune response. Despite the numerous studies and huge amount of data regarding these proteins, the structural basis of their functioning has not yet been clearly elucidated. Scientists from IBCh RAS, together with their colleagues from Moscow Institute of Physics and Technology and Changchun Institute of Applied Chemistry (China) discovered the essential role of zinc in the functioning of Toll-like receptor 1 and proposed possible mechanisms of zinc-mediated receptor activation. The work was funded by the RFBR grant 20-34-70024 and published in Communications Biology. 

Scientists from the Laboratory of biomolecular modeling of the IBCh RAS, together with colleagues from Columbia University (New York, USA), the University of Illinois (Peoria, USA), and the Institute of Physiology of the Czech Academy of Sciences (Prague, Czech Republic), have revealed the structural mechanism of heat-induced opening of temperature-sensitive TRP channels.

Lipids 2021 Conference, October 11-13, 2021, IBCH RAS, Moscow