An “Ancient” Frog Gene Accelerates Skin Wound Healing in Mice
Researchers from the Department of Genomics and Postgenomic Technologies at the State Research Center Institute of Bioorganic Chemistry of the Russian Academy of Sciences and the Department of Regenerative Medicine at Pirogov Russian National Research Medical University have shown that the ag1 gene, an important regulator of regeneration in amphibians that was lost in all amniotes, including reptiles, birds, and mammals, during evolution, can accelerate skin wound healing when introduced into the mouse genome. Activation of this gene in transgenic mice was found to trigger molecular programs associated with regeneration-biased and scar- reduced tissue repair. These findings open new perspectives for fundamental research in tissue regeneration and repair. The results are published in Frontiers in Cell and Developmental Biology. Learn more
News 
- School for Young Scientists: "Objects and Methods of Developmental Biology: Genomic, Molecular, and Morphogenetic Mechanisms of Development and Regeneration"
conferences
IX.4 From September 24-27, 2026, the Koltsov Institute of Developmental Biology of the Russian Academy of Sciences will host a school for young scientists entitled "Objects and Methods of Developmental Biology: Genomic, Molecular, and Morphogenetic Mechanisms of Development and Regeneration." The school is dedicated to the 150th anniversary of the birth of the eminent embryologist D.P. Filatov (1876–1943). It is supported by the Russian Science Foundation (grant no. 23-74-30005). Venue: IBD RAS (Moscow, 26 Vavilova St.).
- Scientists from IBCh RAS and their colleagues describe a new type of luciferase from a previously unexplored bioluminescent system
science news
VII.31 Scientists from the Institute of Bioorganic Chemistry of the Russian Academy of Sciences (IBCh RAS) and their colleagues have identified, cloned and characterized the luciferase of the fungus gnat Keroplatus testaceus for the first time. The study strongly suggests that the newly identified enzyme evolved from the storage protein hexamerin, revealing a previously unknown evolutionary pathway for the emergence of bioluminescence in insects. These findings reveal the molecular basis of light emission in dipteran insects and pave the way for the development of new biomedical imaging tools.
- The stepwise mechanism of TRPV6 channel blockade by polyamine spermine
science news
VI.3 Researchers from IBCh RAS, as part of an international collaboration, have elucidated the mechanism by which the natural polyamine spermine blocks the human calcium channel TRPV6. The study was supported by the Russian Ministry of Science and Higher Education (computational modeling) and published in Nature Communications.
Events 
- Open seminar of the Department of Immunology
science news
VI.8 (This event is over) Dear colleagues! On June 8 (Monday) at 3 p.m., an open seminar of the Department of Immunology will be held in seminary room 404 (4th floor, 52nd building), dedicated to the pre-defense of the dissertation for the degree of Candidate of Biological Sciences Anastasia I. Palamarchuk on the topic: "Overexpression of the telomerase catalytic subunit gene as a factor influencing the transcriptional and functional activity of NK cells, as well as their sensitivity to targeted elimination", specialty 1.5.3. Molecular Biology. Everyone is invited to attend. June 8th

