Laboratory of comparative and functional genomics

Department of Genomics of Adaptive Immunity

Head: Yuri Lebedev

Human genome, genome evolution and variability, retroelements, regulation of gene expression, transcriptome of human lymphocytes, autoimmune diseases

The laboratory was formed early in 2006 and was joined by those of young scientists and PhD students from Laboratory of structure and functions of human genes (LSFHG, laboratory head — academician E.D. Sverdlov) who studied retroposon’s impact on human genome evolution and functioning. On March 2009, Laboratory of comparative and functional genomics includes: laboratory head Y.B. Lebedev, D.Sci., researchers I.Z. Mamedov, Ph.D. and A.L. Amosova, Ph.D., junior researcher S.V. Ustyugova, Ph.D., PhD students A.V. Chkalina, I.V. Zvyagin, A.Y. Komkov, and three undergraduate students from Moscow State University who work on their bachelor’s theses. Ongoing laboratory projects are supported by the Institute, by Russ. Acad. Sci. Presidium programs, by RFBR grants and by other grants, including:

  • Studies of human genome variability and genetic basis of inherited diseases;
  • New approach to identification and selective suppression of expanded T-cell clones in patients with autoimmune and oncological diseases;
  • Role of retroposon’s insertional polymorphism in oncological diseases;
  • Large-scale functional analysis of human specific and polymorphic retroelement insertions;
  • Advanced molecular-genetic markers and their application for people genetic services and records;
  • Molecular-genetic analysis of eneolithic/bronze age inhabitants of Thrace valley and South-Russian steppe.

The laboratory carries out a wide range of molecular genetic research applying newly developed techniques and approaches to comparative analysis of genomic DNAs and cDNA pools of various origins. Ongoing research includes the following directions:

  1. genetics of distinct types of autoimmune diseases associated with clonal T-cell expansion; comparative transcriptome analysis of various subpopulations of peripheral blood lymphocytes;
  2. transposable elements impact on the eukaryotic genome evolution; investigation of genomic variability of individuals and within human population forming by retroelements activity; studies on the interaction between species-specific and polymorphic retroelements and gene expression systems;
  3. development of new aproaches for analysis of individual T-cell repertoires;
  4. studying of clonal diversity dynamic of human T- and B-lymphocytes in normal state and during development of autoimmune or oncological diseases.

Yuri Lebedev

Russia, Moscow, Ul. Miklukho-Maklaya 16/10 — On the map