Laboratory of ligand-receptor interactions
Laboratory was organised in 2009 and is headed by Dr. Igor Kasheverov
The main scope of the Ligand-receptor interactions lab is structure-function relationships of natural and artificial peptide ligands of several Cys-loop receptors (nAChR, GlyR and GABAA). Construction of completely new active compounds based on known anticholinergic ligands is also in the field of our interest.
The lab conducts computer-aided design of new compounds based on diverse conotoxins of different structural classes and modelling of their complexes with nicotinic receptors (nAChR) and acetylcholine-binding proteins (AChBP). We have at our disposal eqipment for peptide synthesis, chromatography and mass-spectrometry, which is used for synthesys and characterization of active compounds. We also have electrophysiology and radioligand assay eqipment for ligans activities research.
Our lab contacts has lots of international collaborations in Germany, France, Finland, Greece, China and Vietnam. And we are open to new contacts!
Previously, more than forty diverse conotoxins analogs were synthetized and studied in the lab. Partly these studies could be represented by following reviews:
Tsetlin V., Utkin Y., Kasheverov I. (2009). Polypeptide and peptide toxins, magnifying lenses for binding sites in nicotinic acetylcholine receptors. Biochem Pharmacol. 78(7), 720—731
Kasheverov I.E., Utkin Y.N., Tsetlin V.I. (2009). Naturally occurring and synthetic peptides acting on nicotinic acetylcholine receptors. Curr Pharm Des. 15(21), 2430—2452.
|Igor' Kasheverov, D.Sc||pr. r. f.|
|Elena Kryukova, Ph.D.||s. r. f.|
|Denis Kudryavtsev, Ph.D.||s. r. firstname.lastname@example.org|
|Raitman O.A., Ph.D.||s. r. f.|
|Igor Ivanov||r. f.|
|Kopylova N.V.||j. r. f.|
|Vera Mozhaeva||j. r. f.||Veramozhaev@yandex.ru|
|Nikolaev G.M.||j. r. f.|
|Gondarenko E.A.||res. eng.|
|Vorontsova O.V.||res. eng.|
|Arhangel'skaya P.S.||t. q. - lab. as.|
|Belyaeva A.Y.||t. q. - lab. as.|
|Inna Holoshenko||t. q. - lab. as.|
|Maiorov V.A.||t. q. - lab. as.|
|Stukalova A.Y.||t. q. - lab. as.|
|Maxim Zhmak, Ph.D.|
Russia, Moscow, Ul. Miklukho-Maklaya 16/10 On the map